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ABS461 Anti-SHOC2 Antibody

Detect Leucine-rich repeat protein SHOC-2 using this rabbit polyclonal antibody, Anti-SHOC2 Antibody validated for use in western blotting & IHC.

Anti-SHOC2 Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Signaling Research Sub-Category: Developmental Signaling Gene Symbol: SHOC2 UniProt Number: Q9UQ13
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ABS461
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABS461
      DescriptionAnti-SHOC2 Antibody
      Alternate Names
      • Leucine-rich repeat protein SHOC-2
      • Ras-binding protein Sur-8
      • SOC2
      • Protein soc-2 homolog
      • Protein sur-8 homolog
      Background InformationThe Leucine-rich repeat protein SHOC-2 (SHOC2) is the regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and plays a key role in MAPK pathway activation. Upon RAS activation, SHOC2 acts as a positive modulator of the RAS-MAPK signaling via specifically allowing PP1c to dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity. SHOC2 localizes to cytoplasm when inactive but rapidly translocates to the nucleus when activated, such as during growth factor stimulation. Thus, as expected, SHOC2 also participates in FGF receptor signaling. Molecularly, SHOC2 is a scaffold protein that brings together activated Ras (activated via G-protein coupled receptors and the interaction of GTP to GDP) and Raf, which then facilitates the transfer of the phospho-Raf phosphate to other proteins for the activation of the MAP Kinase pathway for gene activation. Defects in SHOC2 lead to a type of multi-symptomatic disorder termed the Noonan Syndrome Loss of Anagen Hair (NSLAH) that affects everything from skeletal formation to facial features and many organs including the brain, skin, muscles, and heart. EMD Millipore’s Anti-SHOC2 rabbit polyclonal antibody has been tested in western blotting and immunohistochemistry in human samples.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Jurkat cell lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Leucine-rich repeat protein SHOC-2 using this rabbit polyclonal antibody, Anti-SHOC2 Antibody validated for use in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: 5 µg/mL from a representative lot detected SHOC2 in human spleen tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human SHOC2.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • SHOC2
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~65 kDa observed. Uniprot describes 2 isoforms at ~60 kDa and ~65 kDa. Uncharacterized bands may appear in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Jurkat cell lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected SHOC2 in 15 µg of Jurkat cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABS461 04053252905728