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Anti-PVR (CD155), clone TX24, Cat. No. MABF2338, is a mouse monoclonal that detects PVR (CD155) and has been tested for use in Flow Cytometry and Inhibition/Function Analysis.
More>>Anti-PVR (CD155), clone TX24, Cat. No. MABF2338, is a mouse monoclonal that detects PVR (CD155) and has been tested for use in Flow Cytometry and Inhibition/Function Analysis. Less<<
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Übersicht
Replacement Information
Description
Catalogue Number
MABF2338-100UG
Description
Anti-PVR (CD155) Antibody, clone TX24
Alternate Names
Poliovirus receptor
Nectin-like protein 5
NECL-5
CD155
Background Information
Poliovirus receptor (UniProt: P15151; also known as Nectin-like protein 5, NECL-5, CD155) is encoded by the PVR (also known as PVS) gene (Gene ID: 5817) in human. CD155 is a single-pass type I, N-glycosylated, membrane protein that mediates NK cell adhesion and triggers NK cell effector functions. It is ubiquitously expressed in various tissues and many human tumors are reported to significantly upregulate its expression. It binds two different NK cell receptors: CD96 and CD226 and these interactions accumulate at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and the target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. CD155 serves as a receptor for poliovirus and may play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with dynein light chain Tctex-type 1 (DYNLT1). It is synthesized with a signal peptide (aa 1-20), which is subsequently cleaved off to generate the mature form that contains an extracellular domain (aa 21-343), a transmembrane domain (aa 344-367), and a cytoplasmic domain (aa 368-417). It contains two Ig-like C2 type domains (aa 145-237 and 233-328), and an Ig-like V-type domain that is shown to be necessary and sufficient for virus binding and uptake. CD155 also has one the immunoreceptor tyrosine-based inhibitor motif (ITIM; aa 396-401) that when phosphorylated by Src kinases binds to the SH2 domain of several SH2-containing phosphatases. (Ref.: Tahara-Hanaoka, S., et al. (2004). International Immunology, Vol. 16, No. 4, pp. 533-538; Iguchi-Manaka, A., et al. (2016). PLoS One. 11(4); e0152982).
References
Product Information
Format
Purified
Presentation
Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application
Anti-PVR (CD155), clone TX24, Cat. No. MABF2338, is a mouse monoclonal that detects PVR (CD155) and has been tested for use in Flow Cytometry and Inhibition/Function Analysis.
Key Applications
Flow Cytometry
Inhibits Activity/Function
Application Notes
Flow Cytometry Analysis: A representative lot detected PVR (CD155) in Flow Cytometry applications (Tahara-Hanaoka, S., et. al. (2004). Int Immunol. 16(4):533-8).
Inhibits Activity/Function: A representative lot partially inhibited the cytotoxicity mediated by T and NK cells. (Tahara-Hanaoka, S., et. al. (2004). Int Immunol. 16(4):533-8).
Biological Information
Immunogen
A recombinant fragment corresponding to 323 amino acids from the extracellular domain of human Poliovirus receptor (CD155).
Epitope
extracellular domain
Clone
TX24
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Specificity
Clone TX24 is mouse monoclonal antibody that detects human Poliovirus receptor (CD155). It targets an epitope within the extracellular domain.
Flow Cytometry Analysis: 1 µg of this antibody detected PVR (CD155) in one million U937 cells.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
CD226 (DNAM-1) is an adhesion molecule involved in NK and T cell-mediated cytotoxicity against certain tumors. Here, we have identified the human poliovirus receptor-related (PRR) family members CD155 [poliovirus receptor (PVR)] and CD112 (nectin-2/PRR-2) as the ligands for human CD226. Ectopic expression of human CD155 and/or CD112 rendered mouse BW5147 T cells more susceptible to IL-2-activated T and NK cell-mediated cytotoxicity, and killing was specifically inhibited by anti-CD226 mAb, demonstrating functional interactions of CD226 with CD155 and CD112. Although the binding affinities between soluble CD226 and CD155 or CD112 were comparable, the homophilic interaction of cell-surface CD112 may adversely affect CD226 binding to CD112. We also demonstrate that ligation of CD226 and LFA-1 with their respective ligands cooperates in triggering cytotoxicity and cytokine secretion by T and NK cells.
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