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ABN439 Anti-PQBP1 Antibody

Anti-PQBP1 is an antibody against PQBP1 for use in WB, IH.

Anti-PQBP1 Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: PQBP1, NPW38, JM26 UniProt Number: O60828
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ABN439
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN439
      DescriptionAnti-PQBP1 Antibody
      Alternate Names
      • Polyglutamine-binding protein 1
      • PQBP-1
      • PQBP 1
      • 38 kDa nuclear protein containing a WW domain
      • Npw38
      • Polyglutamine tract-binding protein 1
      Background InformationPolyglutamine-binding protein 1 (PQBP1), also known as PQBP-1, 38 kDa nuclear protein containing a WW domain, Npw38, Polyglutamine tract-binding protein 1, is encoded by the gene name PQBP1/ NPW38/ JM26. Recent studies have implied that PQBP1 may suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. PQBP1 has also been shown to activate transcription directly, or via association with the transcription machinery. PQBP1 might be involved in ATXN1 mutant-induced cell death. PQBP1 has been shown to interact with POU3F2/Brn-2, ATXN1, TXNL4A, HTT and AR. Interaction with ATXN1 correlates positively with the length of the polyglutamine tract. In addition, PQBP1 interacts with RNA polymerase II large subunit in a phosphorylation-dependent manner. PQBP1 forms a ternary complex with ATXN1 mutant and phosphorylated RNA polymerase II. PQBP1 is widely expressed with high levels in heart, skeletal muscle, pancreas, spleen, thymus, prostate, ovary, small intestine and peripheral blood leukocytes. Mutations in PQBP1 have been associated with Renpenning syndrome 1 (RENS1), an X-linked mental retardation syndrome characterized by mental retardation, microcephaly, short stature, and small testes.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit Polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-PQBP1 is an antibody against PQBP1 for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected PQBP1 in human cardiac myocytes and pancreatic tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the unknown of Human PQBP1.
      Epitopeunknown
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Primate based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PQBP1
      • NPW38
      • JM26
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~38 kDa observed. Predicted to cross-react to Isoforms 1, 2, 3, and 6. Maybe detected upon longer exposure times.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Human Hippocampus tissue lysate.

      Western Blotting Analysis: A 0.5 µg/mL dilution of this antibody detected PQBP1 in 10 µg of Human Hippocampus tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABN439 04055977115895