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MABF275 Anti-MRP8 Antibody/ABCC11, clone 2

This Anti-MRP8 Antibody/ABCC11, clone 2 is validated for use in Western Blotting for the detection of MRP8/ABCC11.

Anti-MRP8 Antibody/ABCC11, clone 2: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: ABCC11, MRP8 UniProt Number: Q96J66
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MABF275
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF275
      DescriptionAnti-MRP8 Antibody/ABCC11, clone 2
      Alternate Names
      • ATP-binding cassette sub-family C member 11
      • Multidrug resistance-associated protein 8
      • MRP-8
      Background InformationMRP8/ABCC11 is an interesting protein important in a wide range of cellular processes from bile acid metabolism to ear wax secretion. MRP8/ABCC11 is involved in the ATP-dependent uptake of lipophilic anions, steroid sulfates and various bile acids and plays roles in cAMP and cGMP metabolism as well. MRP8/ABCC11 is a member of the ABC transporter superfamily of proteins. MRP8/ABCC11 is a membrane bound protein and is widely expressed except in kidney, spleen and colon. MRP8/ABCC11 is also expressed in many cancers including breast cancer where it serves as a conformational marker. Interestingly, earwax is a Mendelian trait and can be wet or dry. The Arg-184 allele of MRP8/ABCC11 gene is responsible for dry ear wax (cerumen).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-MRP8 Antibody/ABCC11, clone 2 is validated for use in Western Blotting for the detection of MRP8/ABCC11.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenRecombinant protein corresponding to human MRP8/ABCC11.
      Clone2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ABCC11
      • MRP8
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~170 kDa observed. The calculated molecular weight of this protein is 154 kDa, it has an isoform at 150 kDa and can run higher due to glycosolation. Uncharacterized bands may be observed in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in SK-BR3 cell lysate.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected MRP8/ABCC11 in 10 µg of SK-BR3 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABF275 04055977112092