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48-602MAG
Buffer Detection Kit for Magnetic Beads
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Anti-Histone H2A.X Antibody, Chicken is a Rabbit Polyclonal Antibody for detection of Histone H2A.X also known as H2AFX & has been validated in WB.
More>>Anti-Histone H2A.X Antibody, Chicken is a Rabbit Polyclonal Antibody for detection of Histone H2A.X also known as H2AFX & has been validated in WB. Less<<
Anti-Histone H2A.X Antibody,Chicken: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. H2A.X, also known as H2AFX, is a variant of Histone H2A that is found in a subset of nucleosomes. H2A.X has a unique C-terminal tail that becomes phosphorylated following double-stranded DNA breaks following irradiation or apoptosis. Phosphorylation of H2A.X on Ser139 is one of the earliest markers for apoptosis and DNA damage.
References
Product Information
Format
Affinity Purified
Control
Chicken heart tissue lysate
Presentation
Purified from rabbit serum by affinity chromatography. Supplied at 1 mg/ml in PBS with 0.1% NaN3.
Applications
Application
Anti-Histone H2A.X Antibody, Chicken is a Rabbit Polyclonal Antibody for detection of Histone H2A.X also known as H2AFX & has been validated in WB.
Key Applications
Western Blotting
Biological Information
Immunogen
The immunogen used was a synthetic peptide TFKSTGVPKEQPGSQ-C, corresponding to a.a. 125-139 of chicken H2A.X, coupled to KLH.
Epitope
a.a. 125-139
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Specificity
Recognizes Chicken H2A.X, Mr 15 kDa.
Species Reactivity
Chicken
Species Reactivity Note
Chicken. Does not recognize human H2A.X. Cross-reactivity with other species has not been tested..
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.
[FUNCTION] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. [SUBUNIT] The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with numerous proteins required for DNA damage signaling and repair when phosphorylated on Ser-140. These include MDC1, TP53BP1, BRCA1 and the MRN complex, composed of MRE11A, RAD50, and NBN. Interaction with the MRN complex is mediated at least in part by NBN. Also interacts with DHX9/NDHII when phosphorylated on Ser-140.
Molecular Weight
15 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance
routinely evaluated by immunoblot on lysates from chicken heart tissue
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at 2-8°C from date of receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Millipore’s Histone H2A antibodies demonstrate specificity against linker histone H2A and its modifications. Millipore’s Histone H2A specific antibodies, proteins, and kits are presented below. Weitere Informationen >>
