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ABN1377 Anti-GPR98 Antibody

Anti-GPR98 Antibody is an antibody against GPR98 for use in Immunohistochemistry.

Anti-GPR98 Antibody : SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Neuroscience Research Sub-Category: GPCR, cAMP/cGMP & Calcium Signaling Gene Symbol: GPR98, KIAA0686, KIAA1943, MASS1, USH2C, VLGR1 UniProt Number: Q8WXG9
ABN1377
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN1377
      DescriptionAnti-GPR98 Antibody
      Alternate Names
      • G-protein coupled receptor 98
      • Monogenic audiogenic seizure susceptibility protein 1 homolog
      • Usher syndrome type-2C protein
      • Very large G-protein coupled receptor 1
      Background InformationG-protein coupled receptor 98 (UniProt Q8WXG9; also known as Monogenic audiogenic seizure susceptibility protein 1 homolog, Usher syndrome type-2C protein, Very large G-protein coupled receptor 1) is encoded by the GPR98 (also known as KIAA0686, KIAA1943, MASS1, USH2C, VLGR1) gene (Gene ID 84059) in human. GPR98, also known as Very Large GPCR receptor 1 (Vlg1R1), is the largest G-protein-coupled receptor (GPCR) known. It is an adhesion-GPCR family receptor expressed in the central nervous system. GPR98 is produced with a signal peptide (a.a. 1-29) sequence, the removal of which yields the mature seven-transmembrane (a.a. 5909-5929, 5940-5960, 5980-6000, 6011-6031, 6060-6080, 6105-6125, 6134-6154) protein with a C-termiinal cytoplasmic domain (a.a. 6155-6306) and a large N-terminal extracellular region (a.a. 30-5908) that contains six epilepsy-associated repeats or EAR domains (a.a. 3189-3534) sandwiched between two clusters of calcium-binding Calx-beta repeats (Calx-beta 1-22/a.a. 30-3172 and Calx-beta 23-35/a.a. 3525-5468), as well as a GPCR-proteolytic site (GPS; a.a. 5853-5902) proximal to the first transmembrane helix. The extreme carboxy-terminus contains a consensus PDZ ligand sequence, suggesting interactions with other cytosolic or cytoskeletal proteins. Although the GPR98 ligand is yet to be identified, GPR98 gene mutations are linked to one form (2C) of Usher syndrome, the most common genetic cause of combined blindness and deafness.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-GPR98 Antibody is an antibody against GPR98 for use in Immunohistochemistry.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected GPR98 in human cochlea tissue sections.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to a sequence from the second Calx-beta repeat of human GPR98.
      EpitopeCalx-beta repeat 2.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityExpected to react with spliced isoform 1 (VLGR1b), isoform 3 (VLGR1c), and isoform 4, but not isoform 2 (VLGR1a) of human GPR98 reported by UniProt (Q8WXG9).
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with non-human primates based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • GPR98
      • KIAA0686
      • KIAA1943
      • MASS1
      • USH2C
      • VLGR1
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight690.1 kDa (isoform 1; VLGR1b), 249.9 kDa (isoform 3; VLGR1c), and 159.1 kDa (isoform 4) calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human retina tissue.

      Immunohistochemistry Analysis: An 1:50 dilution of this antibody detected GPR98 in human retina tissue sections.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABN1377 04055977332292