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MABS1272 Anti-Endothelial Protein C Receptor Antibody, clone 1560

Anti-Endothelial Protein C Receptor, clone 1560, Cat. No. MABS1272, is a rat monoclonal antibody for detection of murine Endothelial Protein C Receptor and is tested for use in Flow Cytometry and Inhibition Assays.

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Research Category: Signaling Gene Symbol: Procr, Epcr UniProt Number: Q64695
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MABS1272
100 μg  
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      Übersicht

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFC, InhibitionRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS1272
      DescriptionAnti-Endothelial Protein C Receptor Antibody, clone 1560
      Alternate Names
      • Activated protein C receptor
      • APC receptor
      • Centrocyclin
      • Centrosomal protein CCD41
      • Endothelial cell protein C receptor
      • CD201
      Background InformationEndothelial protein C receptor (UniProt: Q64695; also known as EPCR, Activated protein C receptor, APC receptor, Centrocyclin, Centrosomal protein CCD41, Endothelial cell protein C receptor, CD201) is encoded by the Procr (also known as Epcr) gene (Gene ID: 19124) in murine species. EPCR is a multi-functional single-pass type I membrane protein that is expressed in endothelial cells. Its expression has also been reported in hematopoietic, neuronal, epithelial progenitor cells, and breast cancer stem cells. It binds to activated protein C and enhances protein C activation by the thrombin-thrombomodulin complex and thereby plays a role in the protein C pathway controlling blood coagulation. It is also shown to play a role in mediating activated protein C-induced cytoprotective effects, including antiapoptotic, anti-inflammatory, and barrier stabilization. EPCR exhibits sequence and 3-dimensional structural homology with the major histocompatibility class 1/CD1 family of proteins, particularly CD1d. It contains a tightly bound phospholipid in the antigen presenting groove and phosphatidylcholine is shown to be the major phospholipid bound to human EPCR. Removal of this lipid results in the loss of protein C binding.
      References
      Product Information
      FormatPurified
      PresentationPurified rat monoclonal antibody IgG2b in PBS without preservatives.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Endothelial Protein C Receptor, clone 1560, Cat. No. MABS1272, is a rat monoclonal antibody for detection of murine Endothelial Protein C Receptor and is tested for use in Flow Cytometry and Inhibition Assays.
      Key Applications
      • Flow Cytometry
      • Inhibition
      Application NotesFlow Cytometry Analysis: A representative lot detected Endothelial Protein C Receptor in Flow Cytometry applications (Li, W., et. al. (2005). J Thromb Haemost. 3(7):1351-9; Balazs, A.B., et. al. (2006). Blood. 107(6):2317-21).

      Inhibition Analysis: A representative lot detected Endothelial Protein C Receptor in Inhibition applications (Li, W., et. al. (2005). J Thromb Haemost. 3(7):1351-9; Disse, J., et. al. (2011). J Biol Chem. 286(7):5756-67).
      Biological Information
      ImmunogenA full length recombinant mouse endothelial protein C receptor.
      Clone1560
      ConcentrationPlease refer to lot specific datasheet.
      HostRat
      SpecificityClone 1560 specifically detects endothelial protein C receptor in murine species.
      IsotypeIgG2bκ
      Species Reactivity
      • Mouse
      Species Reactivity NoteMouse.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Procr
      • Epcr
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight27.19 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in bEND.3 mouse endothelial cells.

      Flow Cytometry Analysis: 1 µg of this antibody detected Endothelial Protein C Receptor in one million bEND.3 mouse endothelial cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.

      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABS1272 04054839204074