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MABF1512 Anti-CD127 (IL-7Ra) (mouse), violetFluor™ 450, clone A7R34 Antibody

Anti-CD127 (IL-7Ra) (mouse), violetFluor™ 450, clone A7R34 Antibody detects level of CD127 and has been published and validated for use in Flow Cytometry.

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Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: Il7r UniProt Number: P16872
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MABF1512
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFCRvioletFluor™ 450Monoclonal Antibody
      Description
      Catalogue NumberMABF1512
      DescriptionAnti-CD127 (IL-7Ra) (mouse), violetFluor™ 450, clone A7R34 Antibody
      Alternate Names
      • Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha or IL-7R subunit alpha or IL-7R-alpha or IL-7RA)
      • CD127
      • CD127 (IL-7Ra)
      Background InformationThe A7R34 antibody is specific for mouse CD127, a 60-90 kDa cell surface protein also known as the Interleukin-7 Receptor alpha chain, or IL-7R alpha. CD127 is typically expressed at the cell surface as a heterodimer with the common gamma chain (CD132). This complex acts as the functional receptor for IL-7, a cytokine important in T and B cell development, and in mature T cell homeostasis. A second cytokine known as Thymic Stromal Lymphopoietin (TSLP) also binds to a receptor complex of CD127 and the TSLPR chain to trigger activation of dendritic cells, and is involved in B cell development, allergy and autoimmunity.The A7R34 antibody may be used as a phenotypic marker for CD127 on immature B cells, on subsets of thymocytes which are double negative (CD4-CD8- ) or single positive (CD4+ or CD8+), and at low levels on mature, peripheral T cells. CD127 is a key marker, when used in combination with CD4 and CD25, to distinguish Treg and effector/memory Treg populations known as T(REM).
      References
      Product Information
      FormatvioletFluor™ 450
      PresentationPurified Rat monoclonal containing 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
      Quality LevelMQ100
      Applications
      ApplicationAnti-CD127 (IL-7Ra) (mouse), violetFluor™ 450, clone A7R34 Antibody detects level of CD127 and has been published and validated for use in Flow Cytometry.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenImmunogen information for this antibody is proprietary information.
      CloneA7R34
      ConcentrationPlease refer to lot specific datasheet.
      HostRat
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • Il7r
      Purification MethodPurified by size-exclusion chromatography
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceThis monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

      Flow Cytometry Analysis: 0.5 μg from a representative lot detected CD127 (IL-7Ra) in one million C57Bl/6 splenocytes.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Note: It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABF1512 04055977292268

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      Kategorien

      Life Science Research > Antibodies and Assays > Primary Antibodies