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MABE302 Anti-2,2,7-Trimethylguanosine Antibody, clone K121

Anti-2, 2, 7-Trimethylguanosine Antibody, clone K121 is a high quality Mouse Monoclonal Antibody for the detection of 2, 2, 7-Trimethylguanosine & has been validated in ICC, PAI & IP.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: RNA Metabolism & Binding Proteins
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MABE302
100 µg  
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      Übersicht

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MICC, IAP, IPMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABE302
      DescriptionAnti-2,2,7-Trimethylguanosine Antibody, clone K121
      Background InformationThe 2,2,7-trimethylguanosine cap structure is found on the 5’ end of small nuclear RNAs and small nucleolar RNAs. Initially, these RNA molecules are capped with 7-monomethylguanosine (m7G) which is then methylated by the trimethylguanosine synthase enzyme to form 2,2,7-trimethylguanosine. The synthesis of 2,2,7-trimethylguanosine occurs in the cytoplasm and is an important marker for nuclear localization of RNA molecules. Capping of RNAs is an important requirement for RNA transport and splicing processes. Uncapped RNAs are rapidly degraded by the 5′ exoribonuclease enzyme. 2,2,7-trimethylguanosine capping may play a role in the expression of viral RNAs.
      References
      Product Information
      FormatPurified
      Control
      • NIH/3T3, HeLa, and A431 cells
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-2, 2, 7-Trimethylguanosine Antibody, clone K121 is a high quality Mouse Monoclonal Antibody for the detection of 2, 2, 7-Trimethylguanosine & has been validated in ICC, PAI & IP.
      Key Applications
      • Immunocytochemistry
      • Immunoaffinity Purification
      • Immunoprecipitation
      Application NotesImmunoaffinity Purification Analysis: A representative lot from an independent laboratory was used in IAP (Krainer, A.R., et al. (1988). Nucleic Acids Res. 16(20):9415-9429.).

      Immunoprecipitation Analysis: A representative lot from an independent laboratory was immunoprecipitated in IP (Moketi, S., et al. (2002). Mol Cell. 10(3):599-609.).
      Biological Information
      Immunogen2,2,7-trimethylguanosine
      CloneK121
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Purification MethodProtein G Purified
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunocytochemistry in NIH/3T3, HeLa, and A431 cells.

      Immunocytochemistry Analysis: A 1:500 dilution of this antibody detected 2,2,7-trimethylguanosine in NIH/3T3, HeLa, and A431 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABE302 04053252595974

      Documentation

      Anti-2,2,7-Trimethylguanosine Antibody, clone K121 SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Anti-2,2,7-Trimethylguanosine Antibody, clone K121 Analysenzertifikate

      TitelChargennummer
      Anti-2,2,7-Trimethylguanosine, clone -2733258 2733258
      Anti-2,2,7-Trimethylguanosine, clone -2792459 2792459
      Anti-2,2,7-Trimethylguanosine, clone -2794502 2794502
      Anti-2,2,7-Trimethylguanosine, clone K121 - 2469297 2469297
      Anti-2,2,7-Trimethylguanosine, clone K121 - 2227177 2227177
      Anti-2,2,7-Trimethylguanosine, clone K121 - 3394664 3394664
      Anti-2,2,7-Trimethylguanosine, clone K121 - 3585811 3585811
      Anti-2,2,7-Trimethylguanosine, clone K121 - 3698177 3698177
      Anti-2,2,7-Trimethylguanosine, clone K121 - 3729383 3729383
      Anti-2,2,7-Trimethylguanosine, clone K121 - 3819932 3819932
      Show more

      Literatur

      ÜbersichtPub Med ID
      Pre-mRNA splicing by complementation with purified human U1, U2, U4/U6 and U5 snRNPs.
      Krainer, A R
      Nucleic Acids Res., 16: 9415-29 (1988)  1987

      Abstract anzeigen       		3141901 3141901

      Broschüre

      Titel
      New Products: Volume 3, 2012