171260 Sigma-AldrichAMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem
AMPK Inhibitor, Compound C, CAS 866405-64-3, is a cell-permeable compound that inhibits KDR/VEGFR2, ALK2/BMPR-I, and AMPK kinase activities (IC₅₀ = 25.1, 148, and 234.6 nM, respectively).
More>> AMPK Inhibitor, Compound C, CAS 866405-64-3, is a cell-permeable compound that inhibits KDR/VEGFR2, ALK2/BMPR-I, and AMPK kinase activities (IC₅₀ = 25.1, 148, and 234.6 nM, respectively). Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: 6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine, Dorsomorphin, AMPK Inhibitor I, BMP Inhibitor I
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
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| 866405-64-3 | C₂₄H₂₅N₅O |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 171260-10MG |
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Kst.-Ampulle | 10 mg |
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| 171260-1MG |
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Kst.-Ampulle | 1 mg |
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| 171260-5MG |
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Kst.-Ampulle | 5 mg |
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| Description | |
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| Overview | A cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50 = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFβR-I, ZAPK, Syk, PKCθ, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100 = 2.5 µM) and VEGF signaling-dependent intersomitic vessel formation (EC50 = 5 µM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No. 317240) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. Also available as a 10 mM solution in DMSO (Cat. No. 171261). |
| Catalogue Number | 171260 |
| Brand Family | Calbiochem® |
| Synonyms | 6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine, Dorsomorphin, AMPK Inhibitor I, BMP Inhibitor I |
| Product Information | |
|---|---|
| CAS number | 866405-64-3 |
| ATP Competitive | Y |
| Form | Light yellow solid |
| Hill Formula | C₂₄H₂₅N₅O |
| Chemical formula | C₂₄H₂₅N₅O |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 171260-10MG | 04055977207156 |
| 171260-1MG | 04055977207149 |
| 171260-5MG | 04055977207163 |
Documentation
AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem SDB
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AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 171260 |
Literatur
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| Hao, J., et al. 2010. ACS Chem.Biol. 5, 245. Yu, P.B., et al. 2008. Nat. Chem. Biol 4, 33. Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970. Lee, M., et al. 2003. J. Biol. Chem. 278, 39653. Inoki, K., et al. 2003. Cell 115, 577. Fryer, L.G., 2002. FEBS Lett. 531, 189. Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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