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149101 1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem

1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8, is an agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: ACPC

Primary Target: Glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex
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149101
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
22059-21-8C₄H₇NO₂

Preis & Verfügbarkeit

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149101-1GM
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      149101-250MG
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          Description
          OverviewAn agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Mimics the effects of glycine on the NMDA receptor ion channel and blocks 3H-glycine binding to rat forebrain membrane (IC50 = 38 nM). Blocks NMDA-induced release of arachidonic acid (IC50 = 131 µM) in cerebellar granule cells. Reduces NMDA-induced cell death in hippocampal neurons.
          Catalogue Number149101
          Brand Family Calbiochem®
          SynonymsACPC
          References
          ReferencesViu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527.
          Zapata, A., et al. 1996. NeuroReport 7, 397.
          Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
          Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937.
          Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992.
          Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115.
          Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.
          Product Information
          CAS number22059-21-8
          ATP CompetitiveN
          FormCrystalline solid
          Hill FormulaC₄H₇NO₂
          Chemical formulaC₄H₇NO₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Application1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8, is an agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex.
          Biological Information
          Primary TargetGlycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex
          Primary Target IC<sub>50</sub>38 nM in blocking 3H-glycine binding to rat forebrain membrane; 131 µM in blocking NMDA-induced release of arachidonic acid; 131 µM in cerebellar granule cells
          Purity≥ 98% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSGZ1110000
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Bestellnummer GTIN
          149101-1GM 07790788059590
          149101-250MG 04055977207521

          Documentation

          1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem SDB

          Titel

          Sicherheitsdatenblatt (SDB) 

          1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem Analysenzertifikate

          TitelChargennummer
          149101

          Literatur

          Übersicht
          Viu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527.
          Zapata, A., et al. 1996. NeuroReport 7, 397.
          Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
          Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937.
          Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992.
          Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115.
          Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.

          Broschüre

          Titel
          Excitotoxic Glutamate Analogs Technical Bulletin
          Pathways and Biomarkers of Glutamatergic Synapse Flyer
          Datenblatt

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-April-2008 RFH
          SynonymsACPC
          DescriptionA potent and selective ligand for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Blocks 3H-glycine binding to rat forebrain membranes (IC50 = 38 nM).
          FormCrystalline solid
          CAS number22059-21-8
          RTECSGZ1110000
          Chemical formulaC₄H₇NO₂
          Structure formulaStructure formula
          Purity≥ 98% by TLC
          SolubilityH₂O (40 mg/ml). May require heating and sonication to achieve complete solubilization.
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Irritant
          ReferencesViu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527.
          Zapata, A., et al. 1996. NeuroReport 7, 397.
          Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
          Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937.
          Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992.
          Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115.
          Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.