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676777 (±)-Verapamil, Hydrochloride - CAS 152-11-4 - Calbiochem

Übersicht

Key Spec Table

CAS #Empirical Formula
152-11-4C₂₇H₃₈N₂O₄ · HCl

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676777-100MG
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      Description
      OverviewA papaverine derivative that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Known to reduce the renal clearance of digoxin. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.
      Catalogue Number676777
      Brand Family Calbiochem®
      SynonymsL-Type Calcium Channel Blocker V
      References
      ReferencesLonsberry, B.B., et al. 1994. Pharmacology 49, 23.
      Shchepotin, I.B., et al. 1994. Anticancer Res. 14, 1027.
      Janis, R., et al. 1987. Adv. Drug Res. 16, 309.
      Product Information
      CAS number152-11-4
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₇H₃₈N₂O₄ · HCl
      Chemical formulaC₂₇H₃₈N₂O₄ · HCl
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetL-type Ca2+ channels
      Purity≥99% by titration (with perchloric acid)
      Physicochemical Information
      Cell permeableN
      Safety Information according to GHS
      RTECSYV8320000
      Safety Information
      R PhraseR: 23/24/25

      Toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-36/37/39-45

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
      Global Trade Item Number
      Bestellnummer GTIN
      676777-100MG 07790788052331