565789 Sigma-Aldrichγ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem
This γ-secretase inhibitor, CAS 209984-56-5, is a cell-permeable dibenzazepine compound that lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model.
More>> This γ-secretase inhibitor, CAS 209984-56-5, is a cell-permeable dibenzazepine compound that lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: (S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine
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Übersicht
| Replacement Information |
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Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 209984-56-5 | C₂₆H₂₃F₂N₃O₃ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 565789-1MG |
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Glasflasche | 1 mg |
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| 565789-500UG |
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Kst.-Ampulle | 500 μg |
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| References | |
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| References | Droy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107. van Es, J.H., et al. 2005. Nature 435, 959. Milano, J., et al. 2004. Toxicol. Sci. 82, 341. |
| Product Information | |
|---|---|
| CAS number | 209984-56-5 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₂₆H₂₃F₂N₃O₃ |
| Chemical formula | C₂₆H₂₃F₂N₃O₃ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
|---|---|
| Primary Target | γ-secretase |
| Primary Target IC<sub>50</sub> | 1.7 nM inhibiting Notch processing in SupT1 cells |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 565789-1MG | 04055977191837 |
| 565789-500UG | 04055977191844 |
Documentation
γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem SDB
| Titel |
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γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
|---|---|
| 565789 |
Literatur
| Übersicht |
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| Droy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107. van Es, J.H., et al. 2005. Nature 435, 959. Milano, J., et al. 2004. Toxicol. Sci. 82, 341. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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