203729 Sigma-Aldrich(+)-Brefeldin A, Eupenicillium brefeldianum - CAS 20350-15-6 - Calbiochem
(+)-Brefeldin A, Eupenicillium brefeldianum, CAS 20350-15-6, specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum to the Golgi apparatus.
More>> (+)-Brefeldin A, Eupenicillium brefeldianum, CAS 20350-15-6, specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum to the Golgi apparatus. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: 1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one
Empfohlene Produkte
Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 20350-15-6 | C₁₆H₂₄O₄ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 203729-1MG |
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Kst.-Ampulle | 1 mg |
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| Description | |
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| Overview | Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function. Inhibitor of HDL-mediated cholesterol efflux. Causes disassembly of the Golgi complex and ER swelling in a variety of mammalian cell lines at <40 ng/ml. Blocks binding of ADP-ribosylation factor to the Golgi and inhibits the GDP-GTP exchange. Inhibits the activity of BIG1 and BIG2, the guanine-nucleotide exchange proteins for ADP-ribosylation factors. Also available as a 25 mM solution in DMSO (Cat. No. 500583). |
| Catalogue Number | 203729 |
| Brand Family | Calbiochem® |
| Synonyms | 1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one |
| Product Information | |
|---|---|
| CAS number | 20350-15-6 |
| ATP Competitive | N |
| Form | White crystalline solid |
| Hill Formula | C₁₆H₂₄O₄ |
| Chemical formula | C₁₆H₂₄O₄ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
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| Primary Target | Blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | N |
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| Toxicological Information |
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| Safety Information according to GHS | |
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| RTECS | GY8410000 |
| Safety Information | |
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| R Phrase | R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. |
| S Phrase | S: 36 Wear suitable protective clothing. |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 203729-1MG | 07790788048389 |
Documentation
(+)-Brefeldin A, Eupenicillium brefeldianum - CAS 20350-15-6 - Calbiochem SDB
| Titel |
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(+)-Brefeldin A, Eupenicillium brefeldianum - CAS 20350-15-6 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 203729 |
Literatur
| Übersicht |
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| Yamagi, R., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2567. Moriango, N., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 12856. Mendez, A.J. 1995. J. Biol. Chem. 270, 5891. Ridgway, N.D., et al. 1995. J. Biol. Chem. 270, 8023. Tsai, S.C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3063. Ktistakis, N.Y., et al. 1992. Nature 356, 344. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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