Composition
Bead size (micrometer)
Loading
DMF
THF
MeOH
Tol.
H20
DCM
Application
Comments
Polystyrene
Styrene cross-linked with divinylbenzene 75 - 150 0.5 - 1.0 3 8 2 7 0 7 Routine and large scale synthesis Most cost-effective but can fail on synthesis of difficult or long sequences
NovaSyn® TG
PEG grafted on polystyrene 90 0.2 - 0.3 5 6 4 5 4 5 Research scale medium to long peptides Pressure resistant, thus ideal for continuous flow
NovaSyn® TGR
PEG grafted on polystyrene 90 0.2 - 0.3 5 6 4 5 4 5 Research scale medium to long peptides Special formulation of NovaSyn TG resin which gives even better results for long peptides
PEGA
Polyacrylamide PEG copolymer 150 - 300 0.2 - 0.4 11 13 13 12 16 13 On-bead enzyme assays Internal bead space accessible to many proteins
NovaGel™ (Champion)
PEG grafted on polystyrene 75 - 150 0.6 - 0.8 7 7.5 4 n/d n/d n/d Synthesis of medium length peptides High-loading and high PEG content make it ideal for preparing medium-length peptides in quantity
NovaPEG (Chemmatrix)
Polyethene cross-linked with PEG 75 - 100 0.4 - 0.6 8 n/d 9 n/d 11 13 Long or difficult peptides Quality of long peptides excellent but yields often low
SpheriTide™
Polylysine cross-linked with sebacic acid 250 - 350 2.7 - 3.3 5 n/d 10 n/d 7 2 Large scale synthesis Very high loading to swell ratio, thus saves on reagent and solvent usage