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506304 TrkB Antagonist, ANA-12 - CAS 219766-25-3 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(2-((2-oxoazepan-3-yl)carbamoyl)phenyl)benzo[b]thiophene-2-carboxamide

Primary Target: TrkB
506304
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Tabulka spec. kláve

CAS #Empirical Formula
219766-25-3C₂₂H₂₁N₃O₃S

Products

Katalogové čísloBalení ks/bal.
5.06304.0001 Skleněná láhev 25 mg
Přidat k oblíbeným položkám
Description
OverviewA cell-permeable thiophene carboxymide derived compound that acts as a direct and selective antagonist of TrkB receptor. Binds to the high affinity site on the extracellular domain of TrkB in a dose-dependent manner (Kd = 10 nM) exhibiting much reduced binding to the low affinity site (Kd =12 µM) indicating that it does not compete with BDNF for the same binding site. Does not affect TrkA or TrkC receptors. Shown to permeate the blood-brain barrier, however, its antagonistic effects are not uniform throughout the brain. Does not affect the survivability of neurons. Reduces anxiety and depression related behavior in mice.
Catalogue Number506304
Brand Family Calbiochem®
SynonymsN-(2-((2-oxoazepan-3-yl)carbamoyl)phenyl)benzo[b]thiophene-2-carboxamide
References
ReferencesCazorla, M., et al. 2011. J. Clin. Invest. 121,1846.
Product Information
CAS number219766-25-3
FormWhite solid
Hill FormulaC₂₂H₂₁N₃O₃S
Chemical formulaC₂₂H₂₁N₃O₃S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetTrkB
Primary Target K<sub>i</sub>10 nM
Purity≥98% by HPLC
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
5.06304.0001 04055977243239