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647950 Triclosan - CAS 3380-34-5 - Calbiochem

A potent antimicrobial agent that inhibits bacterial fatty acid synthesis by selectively targeting Fabl encoded enoyl-acyl carrier protein (ACP) reductase.

Triclosan - CAS 3380-34-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-Chloro-2-(2,4-dichlorophenoxy)phenol

647950
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
3380-34-5C₁₂H₇Cl₃O₂
Description
OverviewA potent antimicrobial agent that inhibits bacterial fatty acid synthesis by selectively targeting Fabl encoded enoyl-acyl carrier protein (ACP) reductase. A slow-binding inhibitor that forms a stable ternary complex (bsFabl.NAD+.triclosan) in Bacillus subtilis.
Catalogue Number647950
Brand Family Calbiochem®
Synonyms5-Chloro-2-(2,4-dichlorophenoxy)phenol
References
ReferencesMcLeod, R., et al. 2001. Int. J. Parasitology 31, 109.
Surolia, N. and Surolia, A., 2001. Nat. Medicine 7, 167.
Heath, R.J., et al. 2000. J. Biol. Chem. 275, 4654.
Heath, R.J., et al. 1999. J. Biol. Chem. 274, 11110.
Hoang, T.T. and Schweizer, H.P. 1999. J. Bacteriol. 181, 5489.
Heath, R.J., et al. 1998. J. Biol. Chem. 273, 30316.
McMurray, L.M., et al. 1998. Nature 394, 531.
Product Information
CAS number3380-34-5
FormWhite powder or crystalline powder
Hill FormulaC₁₂H₇Cl₃O₂
Chemical formulaC₁₂H₇Cl₃O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSKO1100000
Safety Information
R PhraseR: 36/37/38-50/53

Irritating to eyes, respiratory system and skin.
Very toxic to aquatic organisms; may cause long-term adverse effects in the aquatic environment.
S PhraseS: 26-36/39-46-60-61

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing and eye/face protection.
If swallowed, seek medical advice immediately and show this container or label.
This material and its container must be disposed of as hazardous waste.
Avoid release to the environment. Refer to special instructions/safety data sheet.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Environmental Hazard
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
647950 0

Documentation

Triclosan - CAS 3380-34-5 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Triclosan - CAS 3380-34-5 - Calbiochem Certificates of Analysis

TitleLot Number
647950

References

Přehled odkazů
McLeod, R., et al. 2001. Int. J. Parasitology 31, 109.
Surolia, N. and Surolia, A., 2001. Nat. Medicine 7, 167.
Heath, R.J., et al. 2000. J. Biol. Chem. 275, 4654.
Heath, R.J., et al. 1999. J. Biol. Chem. 274, 11110.
Hoang, T.T. and Schweizer, H.P. 1999. J. Bacteriol. 181, 5489.
Heath, R.J., et al. 1998. J. Biol. Chem. 273, 30316.
McMurray, L.M., et al. 1998. Nature 394, 531.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-July-2019 JSW
Synonyms5-Chloro-2-(2,4-dichlorophenoxy)phenol
DescriptionA potent antimicrobial agent that inhibits bacterial fatty acid synthesis by selectively targeting Fab l encoded enoyl-acyl carrier protein (ACP) reductase. A slow binding inhibitor that forms a stable ternary complex (bsFabl.NAD+. triclosan) in Bacillus subtilis. Also inhibits the growth of Plasmodium falciparum by inhibiting the apicomplexan Fab I (IC50 = 154.4 ng/ml for W2 strain and 387 ng/ml for D6 strain).
FormWhite powder or crystalline powder
Intert gas (Yes/No) Packaged under inert gas
CAS number3380-34-5
RTECSKO1100000
Chemical formulaC₁₂H₇Cl₃O₂
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityAqueous NaOH
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Environmental Hazard
ReferencesMcLeod, R., et al. 2001. Int. J. Parasitology 31, 109.
Surolia, N. and Surolia, A., 2001. Nat. Medicine 7, 167.
Heath, R.J., et al. 2000. J. Biol. Chem. 275, 4654.
Heath, R.J., et al. 1999. J. Biol. Chem. 274, 11110.
Hoang, T.T. and Schweizer, H.P. 1999. J. Bacteriol. 181, 5489.
Heath, R.J., et al. 1998. J. Biol. Chem. 273, 30316.
McMurray, L.M., et al. 1998. Nature 394, 531.