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616404 Tpl2 Kinase Inhibitor II - CAS 1186649-59-1 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(Cycloheptylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine, hydrate, Tumor Progression Locus 2 Kinase Inhibitor II

616404
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
1186649-59-1C₂₂H₂₄N₆ • H₂O
Description
Overview

This product has been discontinued.



A cell-permeable naphthyridine-cyclohexyl Tpl2 Kinase Inhibitor (Cat. No. 616373) analog that acts as a potent ATP-competitive Tpl2 inhibitor (IC50 = 160 nM) with little activity (IC50 >20 µM) against EGFR, Src, MEK, p38, PKA, PKC, or S6. Reported to block LPS-induced TNF-α production both in vitro (IC50 = 0.5 and 4.5 µM using human monocytes and whole blood, respectively) and in rats in vivo (10 mg/kg, i.p.).
Catalogue Number616404
Brand Family Calbiochem®
Synonyms4-(Cycloheptylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine, hydrate, Tumor Progression Locus 2 Kinase Inhibitor II
References
ReferencesKaila, N., et al. 2007. Bioorg. Med. Chem. 15, 6425.
Product Information
CAS number1186649-59-1
FormPale yellow solid
Hill FormulaC₂₂H₂₄N₆ • H₂O
Chemical formulaC₂₂H₂₄N₆ • H₂O
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
616404 0

Documentation

Tpl2 Kinase Inhibitor II - CAS 1186649-59-1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Tpl2 Kinase Inhibitor II - CAS 1186649-59-1 - Calbiochem Certificates of Analysis

TitleLot Number
616404

References

Přehled odkazů
Kaila, N., et al. 2007. Bioorg. Med. Chem. 15, 6425.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
Synonyms4-(Cycloheptylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine, hydrate, Tumor Progression Locus 2 Kinase Inhibitor II
DescriptionA cell-permeable naphthyridine-cyclohexyl Tpl2 Kinase Inhibitor (Cat. No. 616373) analog that acts as a potent ATP-competitive Tpl2 inhibitor (IC50 = 160 nM) with little activity (IC50 >20 µM) against EGFR, Src, MEK, p38, PKA, PKC, or S6. Reported to block LPS-induced TNF-α production both in vitro (IC50 = 0.5 and 4.5 µM using human monocytes and whole blood, respectively) and in rats in vivo (10 mg/kg, i.p.).
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1186649-59-1
Chemical formulaC₂₂H₂₄N₆ • H₂O
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml) or Ethanol (1 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKaila, N., et al. 2007. Bioorg. Med. Chem. 15, 6425.