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530409 TLR8 Agonist, cpd14b - CAS 1607440-08-3 - Calbiochem

530409
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Tabulka spec. kláve

CAS #Empirical Formula
1607440-08-3C₁₄H₁₈N₂

Products

Katalogové čísloBalení ks/bal.
5.30409.0001 Skleněná láhev 10 mg
Description
OverviewA pentyl-quinoline derived compound that acts as a pure, potent agonist of Toll-like receptor 8 agonist (TLR8, EC50 = 200 nM in a human TLR8-specifc reporter gene assay). Does not affect TLR2, 3, 4, 5, 7, 9, 10, Nod1 and Nod2, and is devoid of any TLR7 activity. Shown to induce activities of several cytokines and chemokines, including IL-1a, IL-1b, IL-6, IL-8, IL-10, IL12, IL-18, IFN-g, CCL20, RANTES, GRO, GM-CSF, and Eotaxin (~ 10 mg/ml).

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number530409
Brand Family Calbiochem®
SynonymsToll-Like Receptor 8 Agonist
References
ReferencesKokatla, H. P., et al. 2014, ChemMedChem9, 719.
Product Information
CAS number1607440-08-3
FormWhite powder
Hill FormulaC₁₄H₁₈N₂
Chemical formulaC₁₄H₁₈N₂
ReversibleY
Quality LevelMQ100
Biological Information
Primary TargetTLR8
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
5.30409.0001 04055977260793