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01-209 TGFβ1

TGFβ1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Cell Culture UniProt Number: P01137 Entrez Gene Number: NM_000660.3
01-209
1 µg  
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Key ApplicationsSpeciesSource
CULTHuman Recombinant human TGF-Beta 1 expressed in insect cells.
Description
Catalogue Number01-209
Brand Family Upstate
Trade Name
  • Upstate
DescriptionTGFβ1
References
Product Information
PresentationLypholized from sodium citrate, pH 3.5
Applications
Key Applications
  • Cell Culture
Application NotesATP endpoint assay for cell number
Biological Information
SourceRecombinant human TGF-Beta 1 expressed in insect cells.
Entrez Gene Number
Entrez Gene SummaryTGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA (MIM 190170) in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for this peptide. TGFB1, TGFB2 (MIM 190220), and TGFB3 (MIM 190230) all function through the same receptor signaling systems.[supplied by OMIM]
Gene Symbol
  • TGFB1
  • TGFB
  • DPD1
  • CED
  • TGF-beta-1
Purification MethodSterilized through a 0.2 micron membrane filter
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P01137 # Multifunctional protein that control proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGFB1 and essentially all of them have specific receptors for this protein. It regulates the actions of many other growth factors and determines a positive or negative direction of their effects. It plays an important role in bone remodeling. It is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.
SIZE: 390 amino acids; 44341 Da
SUBUNIT: The inactive form consists of a TGFB1 homodimer non- covalently linked to a latency-associated peptide (LAP) homodimer. The inactive complex can contain a latent TGFB1-binding protein. The active form is a homodimer of mature TGFB1; disulfide-linked. Heterodimers of TGFB1/TGFB2 have been found in bone. Interacts with CD109 and DPT.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Highly expressed in bone.
PTM: Glycosylated. & The precursor is cleaved into mature TGF-beta-1 and LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive.
DISEASE: SwissProt: P01137 # Defects in TGFB1 are the cause of Camurati-Engelmann disease (CED) [MIM:131300]; also known as progressive diaphyseal dysplasia 1 (DPD1). CED is an autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision.
SIMILARITY: SwissProt: P01137 ## Belongs to the TGF-beta family.
Stem Cell Type
  • Neural Stem Cells
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated in an ATP endpoint assay.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Packaging Information
Material Size1 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
01-209 04053252514593

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Kategorie

Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors