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567805 Src Kinase Inhibitor I - CAS 179248-59-0 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(4ʹ-Phenoxyanilino)-6,7-dimethoxyquinazoline, VEGFR Tyrosine Kinase Inhibitor XV, VEGFR2 Kinase Inhibitor XIII

Primary Target: Src
567805
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
179248-59-0C₂₂H₁₉N₃O₃
Description
Overview

This product has been discontinued.



A 4′-phenoxy substituted 4-anilinoquinazoline compound that acts as a potent, selective, dual site, cell-permeable, reversible and ATP-competitive inhibitor of Src family tyrosine kinases (IC50 = 44 nM and 88 nM for Src and Lck, respectively). Shown to simultaneously interact with both the ATP- and peptide-binding sites. Inhibits VEGFR2 and c-fms tyrosine kinases at much higher concentrations (IC50 = 0.32 µM and 30 µM, respectively).
Catalogue Number567805
Brand Family Calbiochem®
Synonyms4-(4ʹ-Phenoxyanilino)-6,7-dimethoxyquinazoline, VEGFR Tyrosine Kinase Inhibitor XV, VEGFR2 Kinase Inhibitor XIII
References
ReferencesTian, G., et al. 2001. Biochemistry 40, 7084.
Product Information
CAS number179248-59-0
ATP CompetitiveY
FormOff-white solid
Hill FormulaC₂₂H₁₉N₃O₃
Chemical formulaC₂₂H₁₉N₃O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetSrc
Primary Target IC<sub>50</sub>44 nM and 88 nM for Src and Lck, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
567805 0

Documentation

Src Kinase Inhibitor I - CAS 179248-59-0 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Src Kinase Inhibitor I - CAS 179248-59-0 - Calbiochem Certificates of Analysis

TitleLot Number
567805

References

Přehled odkazů
Tian, G., et al. 2001. Biochemistry 40, 7084.

Citations

Název
  • Malcolm A. Meyn, et al. (2005) Src family kinase activity is required for murine embryonic stem cell growth and differentiation. Molecular Pharmacology 68, 1320-1330.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision12-January-2010 RFH
    Synonyms4-(4ʹ-Phenoxyanilino)-6,7-dimethoxyquinazoline, VEGFR Tyrosine Kinase Inhibitor XV, VEGFR2 Kinase Inhibitor XIII
    DescriptionA potent, selective, dual site, cell-permeable, reversible and ATP-competitive inhibitor of Src tyrosine kinase (IC50 = 44 nM and 88 nM for Src and Lck, respectively). Shown to simultaneously interact with both the ATP- and peptide-binding sites. Inhibits VEGFR2 and c-fms tyrosine kinases only at higher concentrations (IC50 = 320 nM and 30 µM, respectively).
    FormOff-white solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number179248-59-0
    Chemical formulaC₂₂H₁₉N₃O₃
    Structure formulaStructure formula
    Purity≥95% by HPLC
    SolubilityDMSO (5 mg/ml)
    Storage Protect from light
    +2°C to +8°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    Toxicity Standard Handling
    ReferencesTian, G., et al. 2001. Biochemistry 40, 7084.
    Citation
  • Malcolm A. Meyn, et al. (2005) Src family kinase activity is required for murine embryonic stem cell growth and differentiation. Molecular Pharmacology 68, 1320-1330.
    		•