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573095 STAT3 Inhibitor Peptide

STAT3 Inhibitor Peptide MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ac-PpYLKTK-OH, STAT3 Inhibitor I

Primary Target: STAT3
573095
  
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Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₃₈H₆₃N₈O₁₃P
Description
Overview

This product has been discontinued.



A Stat3-SH2 domain binding phosphopeptide that acts as a selective inhibitor of Stat3 (signal transducers and activators of transcription 3) signaling with a DB50 of 235 µM (concentration of peptide at which DNA-binding activity is inhibited by 50%). Significantly lowers the DNA-binding activity of Stat3 by forming an inactive Stat3:peptide complex and reduces the levels of active Stat3:Stat3 dimers that can bind DNA. Displays greater affinity for Stat3, and to a lesser extent Stat1, over Stat5.
Supplied as a trifluoroacetate salt.
Catalogue Number573095
Brand Family Calbiochem®
SynonymsAc-PpYLKTK-OH, STAT3 Inhibitor I
References
ReferencesTurkson, J., et al. 2001. J. Biol. Chem. 276, 45443.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₃₈H₆₃N₈O₁₃P
Chemical formulaC₃₈H₆₃N₈O₁₃P
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetSTAT3
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceAc-Pro-Tyr(PO₃H₂)-Leu-Lys-Thr-Lys-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
573095 0

Documentation

STAT3 Inhibitor Peptide MSDS

Title

Safety Data Sheet (SDS) 

STAT3 Inhibitor Peptide Certificates of Analysis

TitleLot Number
573095

References

Přehled odkazů
Turkson, J., et al. 2001. J. Biol. Chem. 276, 45443.

Technical Info

Title
JAK/STAT Signaling Research Focus
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-September-2008 RFH
SynonymsAc-PpYLKTK-OH, STAT3 Inhibitor I
DescriptionA Stat3-SH2 domain binding phosphopeptide that acts as a selective inhibitor of Stat3 (signal transducers and activators of transcription 3) signaling with a DB50 of 235 µM (concentration of peptide at which DNA-binding activity is inhibited by 50%). Significantly lowers the DNA-binding activity of Stat3 by forming an inactive Stat3:peptide complex and reduces the level of active Stat3:Stat3 dimer that can bind DNA. Displays greater affinity for Stat3, and to lesser extent Stat1 over Stat5.
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₈H₆₃N₈O₁₃P
Peptide SequenceAc-Pro-Tyr(PO₃H₂)-Leu-Lys-Thr-Lys-OH
Purity≥95% by HPLC
SolubilityH₂O (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesTurkson, J., et al. 2001. J. Biol. Chem. 276, 45443.