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567310 SKF-96365, Hydrochloride - CAS 130495-35-1 - Calbiochem

Inhibits receptor-mediated Ca2+ entry in activated platelets, neutrophils, and endothelial cells at concentrations that do not affect internal Ca2+ release.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-[β-[3-(4-Methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole, HCl

Primary Target: Inhibits receptor-mediated Ca2+ entry
567310
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
130495-35-1C₂₂H₂₆N₂O₃ . HCl

Products

Katalogové čísloBalení ks/bal.
567310-5MG Plastová ampulka 5 mg
Description
OverviewInhibits receptor-mediated Ca2+ entry in activated platelets, neutrophils, and endothelial cells at concentrations that do not affect internal Ca2+ release. Also inhibits voltage-gated Ca2+ entry in excitable cells. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.
Catalogue Number567310
Brand Family Calbiochem®
Synonyms1-[β-[3-(4-Methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole, HCl
References
ReferencesLeung, Y.-M., et al. 1996. Biochem. Pharmacol. 51, 605.
Schwartz, G., et al. 1994. Cell Calcium 15, 45.
Cabello, O.A. and Schilling, W.P. 1993. Biochem. J. 295, 357.
Graier, W.F., et al. 1992. Biochem. Biophys. Res. Commun. 186, 1539.
Blayney, L.M., et al. 1991. Biochem. J. 273, 803.
Fasolato, C., et al. 1990. J. Biol. Chem. 265, 20351.
Merritt, J.E., et al. 1990. Biochem. J. 271, 515.
Product Information
CAS number130495-35-1
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₂H₂₆N₂O₃ . HCl
Chemical formulaC₂₂H₂₆N₂O₃ . HCl
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetInhibits receptor-mediated Ca2+ entry
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
567310-5MG 04055977267204

Documentation

SKF-96365, Hydrochloride - CAS 130495-35-1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

SKF-96365, Hydrochloride - CAS 130495-35-1 - Calbiochem Certificates of Analysis

TitleLot Number
567310

References

Přehled odkazů
Leung, Y.-M., et al. 1996. Biochem. Pharmacol. 51, 605.
Schwartz, G., et al. 1994. Cell Calcium 15, 45.
Cabello, O.A. and Schilling, W.P. 1993. Biochem. J. 295, 357.
Graier, W.F., et al. 1992. Biochem. Biophys. Res. Commun. 186, 1539.
Blayney, L.M., et al. 1991. Biochem. J. 273, 803.
Fasolato, C., et al. 1990. J. Biol. Chem. 265, 20351.
Merritt, J.E., et al. 1990. Biochem. J. 271, 515.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-October-2019 JSW
Synonyms1-[β-[3-(4-Methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole, HCl
DescriptionInhibits receptor-mediated Ca2+ entry in stimulated platelets (IC50 = 8-12 µM in intact platelets), neutrophils, and endothelial cells (IC50 = 30 µM for human endothelial cells) at concentrations that do not affect internal Ca2+ release. Also inhibits voltage-gated Ca2+ entry in excitable cells. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.
FormWhite solid
CAS number130495-35-1
Chemical formulaC₂₂H₂₆N₂O₃ . HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (2 mg/ml)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesLeung, Y.-M., et al. 1996. Biochem. Pharmacol. 51, 605.
Schwartz, G., et al. 1994. Cell Calcium 15, 45.
Cabello, O.A. and Schilling, W.P. 1993. Biochem. J. 295, 357.
Graier, W.F., et al. 1992. Biochem. Biophys. Res. Commun. 186, 1539.
Blayney, L.M., et al. 1991. Biochem. J. 273, 803.
Fasolato, C., et al. 1990. J. Biol. Chem. 265, 20351.
Merritt, J.E., et al. 1990. Biochem. J. 271, 515.