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505484 SB-277011-A Dihydrochloride - CAS 1226917-67-4 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: SB277011A, SB 277011A, Dopamine D3 Receptor Antagonist, SB-277011-A, SB-277011A

Primary Target: D3
505484
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
1226917-67-4C₂₈H₃₀N₄O•2HCl

Products

Katalogové čísloBalení ks/bal.
5.05484.0001 Skleněná láhev 5 mg
Description
OverviewA brain-penetrant, high-affinity, and selective dopamine D3 receptor antagonist. High affinity for the hD3 receptor (pKi = 7.95) with 100-fold selectivity over the hD2 receptor and over 66 other receptors, enzymes, and ion channels. Rat data shows that the compound is selective for the D3 receptor over certain serotonergic and cholinergic receptors at doses up to 56.0 mg/kg and strong physiological response at 32.0 mg/kg.
Catalogue Number505484
Brand Family Calbiochem®
SynonymsSB277011A, SB 277011A, Dopamine D3 Receptor Antagonist, SB-277011-A, SB-277011A
References
ReferencesCollins, G. T. et al. 2005. J. Pharmacol. Exp. Ther. 314, 310.
Reavill, C. et al. 2000. J. Pharmacol. Exp. Ther. 294, 1154.
Product Information
CAS number1226917-67-4
FormWhite solid
Hill FormulaC₂₈H₃₀N₄O•2HCl
Chemical formulaC₂₈H₃₀N₄O•2HCl
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetD3
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
5.05484.0001 04055977243369

Documentation

SB-277011-A Dihydrochloride - CAS 1226917-67-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Přehled odkazů
Collins, G. T. et al. 2005. J. Pharmacol. Exp. Ther. 314, 310.
Reavill, C. et al. 2000. J. Pharmacol. Exp. Ther. 294, 1154.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-September-2013 JSW
SynonymsSB277011A, SB 277011A, Dopamine D3 Receptor Antagonist, SB-277011-A, SB-277011A
DescriptionA brain-penetrant, high-affinity, and selective dopamine D3 receptor antagonist. High affinity for the hD3 receptor (pKi = 7.95) with 100-fold selectivity over the hD2 receptor and over 66 other receptors, enzymes, and ion channels. Rat data shows that the compound is selective for the D3 receptor over certain serotonergic and cholinergic receptors at doses up to 56.0 mg/kg and strong physiological response at 32.0 mg/kg.
FormWhite solid
CAS number1226917-67-4
Chemical formulaC₂₈H₃₀N₄O•2HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (100 mM)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesCollins, G. T. et al. 2005. J. Pharmacol. Exp. Ther. 314, 310.
Reavill, C. et al. 2000. J. Pharmacol. Exp. Ther. 294, 1154.