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506415 SB-269970 Hydrochloride - CAS 261901-57-9 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-HT7 Serotonin receptor antagonist, SB-269970, SB 26,970, SB 26,970

Primary Target: 5-HT₇
506415
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Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
261901-57-9C₁₈H₂₈N₂O₃S·HCl

Products

Katalogové čísloBalení ks/bal.
5.06415.0001 Skleněná láhev 10 mg
Description
OverviewA selective 5-HT7 receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT7 receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT7 antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B).
Catalogue Number506415
Brand Family Calbiochem®
Synonyms5-HT7 Serotonin receptor antagonist, SB-269970, SB 26,970, SB 26,970
References
ReferencesTokarski, K. et al. 2012. Pharmacol. Rep. 64, 256.
Thomas. D. R. et al. 2000. Br. J. Pharmacol. 130, 409.
Lovell, P. J. et al. 2000. J. Med. Chem. 43, 342.
Forbes, I. T. et al. 1998. J. Med. Chem. 41, 655.
Product Information
CAS number 261901-57-9
FormOff-white solid
Hill FormulaC₁₈H₂₈N₂O₃S·HCl
Chemical formulaC₁₈H₂₈N₂O₃S·HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target5-HT₇
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
5.06415.0001 04055977243314

Documentation

SB-269970 Hydrochloride - CAS 261901-57-9 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Přehled odkazů
Tokarski, K. et al. 2012. Pharmacol. Rep. 64, 256.
Thomas. D. R. et al. 2000. Br. J. Pharmacol. 130, 409.
Lovell, P. J. et al. 2000. J. Med. Chem. 43, 342.
Forbes, I. T. et al. 1998. J. Med. Chem. 41, 655.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-September-2013 JSW
Synonyms5-HT7 Serotonin receptor antagonist, SB-269970, SB 26,970, SB 26,970
DescriptionA selective 5-HT7 receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT7 receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT7 antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B).
FormOff-white solid
CAS number 261901-57-9
Chemical formulaC₁₈H₂₈N₂O₃S·HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTokarski, K. et al. 2012. Pharmacol. Rep. 64, 256.
Thomas. D. R. et al. 2000. Br. J. Pharmacol. 130, 409.
Lovell, P. J. et al. 2000. J. Med. Chem. 43, 342.
Forbes, I. T. et al. 1998. J. Med. Chem. 41, 655.