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555553 Rho Kinase Inhibitor III, Rockout - CAS 7272-84-6 - Calbiochem

The Rho Kinase Inhibitor III, Rockout, also referenced under CAS 7272-84-6, controls the biological activity of Rho Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & De

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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(4-Pyridyl)-1H-indole

Primary Target: ROCK
555553
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Tabulka spec. kláve

CAS #Empirical Formula
7272-84-6C₁₃H₁₀N₂

Products

Katalogové čísloBalení ks/bal.
555553-10MG Plastová ampulka 10 mg
Přidat k oblíbeným položkám
Description
OverviewA cell-permeable indolopyridine compound that acts as a selective, reversible, and ATP-competitive inhibitor of Rho kinase activity with an IC50 of 25 µM. Does not inhibit the activation of Rho kinase nor does it affect the in vitro activities of MLCK, PKCα, and SAPK2a/p38α. Shown to be 5-fold less potent than Y-27632 (Cat. No. 688000; IC50 = ~5 µM), and display a similar specificity profile as H-89 (Cat. No. 371963). Affects cell migration, inhibits blebbing (IC50 = ~ 12 µM in M2 cells), and decreases stress fibers in Bulb 3T3 cells at 50 µM.
Catalogue Number555553
Brand Family Calbiochem®
Synonyms3-(4-Pyridyl)-1H-indole
References
ReferencesYarrow, J.C., et al. 2005. Chem. Biol. 12, 385.
Product Information
CAS number7272-84-6
ATP CompetitiveY
FormYellow solid
Hill FormulaC₁₃H₁₀N₂
Chemical formulaC₁₃H₁₀N₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetROCK
Primary Target IC<sub>50</sub>25 µM against ROCK
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
555553-10MG 04055977268430