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556770 RNase L Activator - CAS 357618-26-9 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: C-5950331

556770
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
357618-26-9C₁₆H₁₄N₂O₂S
Description
Overview

This product has been discontinued.



A cell-permeable tricyclic fused phenolic compound that induces RNase L dimerization and activation (EC50 = 22 µM) via direct interaction (KD = 12 µM) at the natural activator 2-5A (5'-phosphorylated, 2',5'-oligoadenylates) binding domain. Shown to exhibit broad-spectrum antiviral activity against diverse types of RNA viruses in both murine (EMCV & VSV in MEF) and human (HPIV-3, Sandai, XMRV in HeLa M, HeLa S, and DU145, respectively) cultures, but not in RNase L-deficient MEF culture or HeLa cells expressing inactive RNase L. Although the synthetic compound binds RNase L with a 4- to 6-times slower kinetic and is 44,000-times less potent than a trimer 2-5A (p3A2'p5'A2'p5'A), it is much more permeant and displays no cytotoxicity to MEF or HeLa S cells (50 µM for 24 h).
Catalogue Number556770
Brand Family Calbiochem®
SynonymsC-5950331
References
ReferencesThakur, C.S., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 9585.
Product Information
CAS number357618-26-9
FormOff-white solid
Hill FormulaC₁₆H₁₄N₂O₂S
Chemical formulaC₁₆H₁₄N₂O₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
556770 0

Documentation

RNase L Activator - CAS 357618-26-9 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

RNase L Activator - CAS 357618-26-9 - Calbiochem Certificates of Analysis

TitleLot Number
556770

References

Přehled odkazů
Thakur, C.S., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 9585.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
SynonymsC-5950331
DescriptionA cell-permeable tricyclic fused phenolic compound that induces RNase L dimerization and activation (EC50 = 22 µM) via direct interaction (KD = 12 µM) at the natural activator 2-5A (5'-phosphorylated, 2',5'-oligoadenylates) binding domain. Shown to exhibit broad-spectrum antiviral activity against diverse types of RNA viruses in both murine (EMCV & VSV in MEF) and human (HPIV-3, Sandai, XMRV in HeLa M, HeLa S, and DU145, respectively) cultures, but not in RNase L-deficient MEF culture or HeLa cells expressing inactive RNase L. Although the synthetic compound binds RNase L with a 4- to 6-times slower kinetic and is 44,000-times less potent than a trimer 2-5A (p3A2'p5'A2'p5'A), it is much more permeant and displays no cytotoxicity to MEF or HeLa S cells (50 µM for 24 h).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number357618-26-9
Chemical formulaC₁₆H₁₄N₂O₂S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (25 mg/ml) or Ethanol (2.5 mg/ml at 50-60°C water-bath)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesThakur, C.S., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 9585.