Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

557305 RNAi Enhancer, Enoxacin Sodium Salt - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid, Na salt, RNA Interference Enhancer, Enoxacin Sodium Salt

557305
  
Purchase on Sigma-Aldrich

Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₁₅H₁₆FN₄NaO₃
Description
OverviewA fluoroquinolone antibacterial compound that displays antitumor properties. Shown to bind to the miRNA biosynthesis protein TAR RNA-binding protein 2 (TRBP; Kd = 12.56 µM), enhance RNAi and stimulate miRNA expression. Specifically induces cell-cycle arrest and apoptosis in a panel of 12-cancer cells (EC50 of 124 µM in HCT-116 cells) and suppresses tumor growth in a xenograft mouse model (10 mg/kg, i.p.).
Catalogue Number557305
Brand Family Calbiochem®
Synonyms1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid, Na salt, RNA Interference Enhancer, Enoxacin Sodium Salt
References
ReferencesMelo, S., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 4394.
Zhang, Q., et al. 2008. Cell Res. 18, 1077.
Shan, G., et al. 2008. Nat. Biotechnol. 26, 933.
Product Information
FormWhite to off-white solid
Hill FormulaC₁₅H₁₆FN₄NaO₃
Chemical formulaC₁₅H₁₆FN₄NaO₃
Hygroscopic Hygroscopic
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
557305 0

Documentation

RNAi Enhancer, Enoxacin Sodium Salt - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

RNAi Enhancer, Enoxacin Sodium Salt - Calbiochem Certificates of Analysis

TitleLot Number
557305

References

Přehled odkazů
Melo, S., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 4394.
Zhang, Q., et al. 2008. Cell Res. 18, 1077.
Shan, G., et al. 2008. Nat. Biotechnol. 26, 933.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-October-2017 JSW
Synonyms1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid, Na salt, RNA Interference Enhancer, Enoxacin Sodium Salt
DescriptionA fluoroquinolone antibacterial compound that displays antitumor properties. Shown to bind to the miRNA biosynthesis protein TAR RNA-binding protein 2 (TRBP; Kd = 12.56 µM), enhance RNAi and stimulate miRNA expression. Specifically induces cell-cycle arrest and apoptosis in a panel of 12-cancer cells (EC50 of 124 µM in HCT-116 cells) and suppresses tumor growth in a xenograft mouse model (10 mg/kg, i.p.).
FormWhite to off-white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₅H₁₆FN₄NaO₃
Purity≥97% by HPLC
SolubilityH₂O (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
Toxicity Standard Handling
ReferencesMelo, S., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 4394.
Zhang, Q., et al. 2008. Cell Res. 18, 1077.
Shan, G., et al. 2008. Nat. Biotechnol. 26, 933.