Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

557322 RK-682, Streptomyces sp.

RK-682, Streptomyces sp. MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Hexadecanoyl-5-hydroxymethyl-tetronic Acid

Primary Target: dephosphorylation activity of CD45
557322
  
Purchase on Sigma-Aldrich

Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
154639-24-4C₂₁H₃₆O₅
Description
Overview

This product has been discontinued.





A specific and noncompetitive inhibitor of protein tyrosine phosphatase with limited cell-permeability. Inhibits dephosphorylation activity of CD45 (IC50 = 54 µM) and VHR (vaccinia H1-related; IC50 = 2 µM) in vitro. Inhibits cell cycle progression of Ball-1 cells at the G1/S transition and enhances ATP-induced long-term potentiation in guinea-pig hippocampal CA1 neurons.
Catalogue Number557322
Brand Family Calbiochem®
Synonyms3-Hexadecanoyl-5-hydroxymethyl-tetronic Acid
References
ReferencesFujii, S., et al. 1995. Neurosci. Lett. 187, 130.
Fujii, S., et al. 1995. Neurosci. Lett. 187, 133.
Hamaguchi, T., et al. 1995. FEBS Lett. 372, 54.
Product Information
CAS number154639-24-4
FormPale yellow solid
Hill FormulaC₂₁H₃₆O₅
Chemical formulaC₂₁H₃₆O₅
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targetdephosphorylation activity of CD45
Primary Target IC<sub>50</sub>54 µM
Secondary targetVHR (vaccinia H1-related; IC₅₀ = 2 µM) in vitro protein tyrosine phosphatase cell cycle progression of Ball-1 cells at the G1/S transition and enhances ATP-induced long-term potentiation in guinea-pig hippocampal CA1 neurons
Purity≥98% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
557322 0

Documentation

RK-682, Streptomyces sp. Certificates of Analysis

TitleLot Number
557322

References

Přehled odkazů
Fujii, S., et al. 1995. Neurosci. Lett. 187, 130.
Fujii, S., et al. 1995. Neurosci. Lett. 187, 133.
Hamaguchi, T., et al. 1995. FEBS Lett. 372, 54.

Brochure

Title
Protein Phosphatases Technical Bulletin
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
Synonyms3-Hexadecanoyl-5-hydroxymethyl-tetronic Acid
DescriptionA specific and noncompetitive inhibitor of protein tyrosine phosphatase with limited cell-permeability. Inhibits dephosphorylation activity of CD45 (IC50 = 54 µM) and VHR (vaccinia H1-related; IC50 = 2 µM) in vitro. Inhibits cell cycle progression of Ball-1 cells at the G1/S transition and enhances ATP-induced long-term potentiation in guinea-pig hippocampal CA1 neurons.
FormPale yellow solid
CAS number154639-24-4
Chemical formulaC₂₁H₃₆O₅
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (25 mg/ml) or ethanol (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesFujii, S., et al. 1995. Neurosci. Lett. 187, 130.
Fujii, S., et al. 1995. Neurosci. Lett. 187, 133.
Hamaguchi, T., et al. 1995. FEBS Lett. 372, 54.