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516561 Pertussis Toxin, Bordetella pertussis, Glycerol Solution - CAS 70323-44-3 - Calbiochem

Pertussis Toxin, Bordetella pertussis, Glycerol Solution, CAS 70323-44-3, is a protein endotoxin that catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Islet-activating Protein

516561
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Tabulka spec. kláve

CAS #
70323-44-3

Products

Katalogové čísloBalení ks/bal.
516561-50UG Hliníkový sud 50 μg
Přidat k oblíbeným položkám
Description
OverviewA protein endotoxin that catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins. The holotoxin has five dissimilar subunits S-1, S-2, S-3, S-4, and S-5, in a molar ratio of 1:1:1:2:1, S-1 (A protomer) is responsible for the enzymatic activity of the toxin, and S-2, S-3, S-4, and S-5 form the B oligomer which is responsible for the toxins binding to the cell surface. NOTE: This product is not activated, hence for use in cell-free systems, activation is required.
Catalogue Number516561
Brand Family Calbiochem®
SynonymsIslet-activating Protein
References
ReferencesFryer, M.W. 1992. Neurosci. Lett. 146, 84.
Gierschik, P. 1992. Curr. Topics Microbiol. Immunol. 175, 69.
Harada, J., et al. 1992. Eur. J. Pharmacol. 227, 301.
Hausman, S.Z., and Burns, D.L. 1992. J. Biol. Chem. 267, 13735.
Kaslow, H.R., and Burns, D.L. 1992. FASEB J. 6, 2684.
Zhu, J., et al. 1992. J. Pharmacol. Exp. Therap. 263, 1479
Kaslow, H.R., et al. 1987. Biochemistry 26, 123.
Hewlett, E.L., et al. 1983. Infect. Immun. 40, 1198.
Moss, J., et al. 1983. J. Biol. Chem. 258, 11879.
Product Information
CAS number70323-44-3
ATP CompetitiveN
FormLiquid
FormulationIn 500 mM NaCl, 50 mM Tris, 10 mM glycine, 50% glycerol, pH 7.5.
ReversibleN
Quality LevelMQ200
Biological Information
Biological activity≤1 ng/ml as determined in a clustering assay using CHO cells line
Primary TargetGuanine nucleotide-binding regulatory proteins
Primary Target IC<sub>50</sub>≤1 ng/ml as determined in a clustering assay using CHO cells line
PurityFive distinct bands by SDS-PAGE
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
Cell permeableN
ContaminantsAdenylate cyclase.
Safety Information according to GHS
RTECSXW5883750
Safety Information
R PhraseR: 23/24/25

Toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsA uniform suspension may be achieved by gentle mixing prior to use.
Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
Global Trade Item Number
Katalogové číslo GTIN
516561-50UG 04055977198171