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516485 Pepstatin A Methyl Ester - Calbiochem

A cell-permeable methyl ester derivative of Pepstatin A that acts as a potent, non-competitive, transition-state analog inhibitor of γ-secretase.

Pepstatin A Methyl Ester - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Isovaleryl-V V-Sta-A-Sta-OCH₃, PME

Primary Target: γ-secretase
516485
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Přehled

Tabulka spec. kláve

Empirical Formula
C₃₅H₆₅N₅O₉

Products

Katalogové čísloBalení ks/bal.
516485-1MG Plastová ampulka 1 mg
Přidat k oblíbeným položkám
Description
OverviewA cell-permeable methyl ester derivative of Pepstatin A (Cat. No. 516481) that acts as a potent, non-competitive, transition-state analog inhibitor of γ-secretase (Kis = 150 nM, Kii = 320 nM in solubilized human γ-secretase at 20°C; Kis is the inhibition constant for inhibitor binding to the free enzyme and Kii is the inhibition constant for inhibitor binding to the Enzyme-Substrate complex). Sta = (3S,4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid.
Catalogue Number516485
Brand Family Calbiochem®
SynonymsIsovaleryl-V V-Sta-A-Sta-OCH₃, PME
References
ReferencesTian, G., et al. 2002. J. Biol. Chem. 277, 31499.
Zhang, L., et al. 2001. Biochemistry 40, 5049.
Murphy, M.P., et al. 1999. J. Biol. Chem. 274, 11914.
Product Information
ATP CompetitiveN
FormLyophilized
Hill FormulaC₃₅H₆₅N₅O₉
Chemical formulaC₃₅H₆₅N₅O₉
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary Targetγ-secretase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
516485-1MG 07790788056308