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506350 Pam₃Cys-Ser-(Lys)₄, Hydrochloride

Pam₃Cys-Ser-(Lys)₄, Hydrochloride MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys₄-OH, 3HCl, P₃CSK₄, 3HCl, Pam₃Cys-SK₄, 3HCl, Pam3CSK4, TLR1/TLR2 Agonist I

506350
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Přehled

Replacement Information

Products

Katalogové čísloBalení ks/bal.
506350-2MG Plastová ampulka 2 mg
Description
OverviewA cell-permeable, water-soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Induces the release of IL-1, IL-6, TNF-α, superoxide, and NO. Promotes the translocation of NF-κB, enhances tyrosine protein phosphorylation and activation of ERK1/2 and MEK1/2. Acts as a selective agonist of TLR2 (Toll-like receptor 2).
Catalogue Number506350
Brand Family Calbiochem®
Synonyms(S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys₄-OH, 3HCl, P₃CSK₄, 3HCl, Pam₃Cys-SK₄, 3HCl, Pam3CSK4, TLR1/TLR2 Agonist I
References
ReferencesBarrenschee, M., et al. 2010. PLoS One. 5, e13889.
Zahringer, U., et al. 2008. Immunology. 213, 205.
Toshchakov, V., et al. 2002. Nat. Immunol. 3, 392.
Muller, M.R., et al. 2001. Immunology 103, 49.
Vergne, I., and Cezanne, L. 1999. Eur. J. Biochem. 264, 369.
Diaz-Guerra, M.J., et al. 1996. J. Biol. Chem. 271, 30114.
Offermanns, S., et al. 1992. Biochem. J. 282, 551.
Seifert, R., et al. 1990. Biochem. J. 267, 795.
Hoffmann, P., et al. 1989. Biol. Chem. Hoppe. Seyler. 370, 575.
Product Information
CAS number112208-00-1
FormLyophilized solid
Hill FormulaC₈₁H₁₅₆N₁₀O₁₃S • 3 HCl
Chemical formulaC₈₁H₁₅₆N₁₀O₁₃S • 3 HCl
Quality LevelMQ100
Applications
Biological Information
Purity≥90% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
506350-2MG 04055977272475

Documentation

Pam₃Cys-Ser-(Lys)₄, Hydrochloride MSDS

Title

Safety Data Sheet (SDS) 

Pam₃Cys-Ser-(Lys)₄, Hydrochloride Certificates of Analysis

TitleLot Number
506350

References

Přehled odkazů
Barrenschee, M., et al. 2010. PLoS One. 5, e13889.
Zahringer, U., et al. 2008. Immunology. 213, 205.
Toshchakov, V., et al. 2002. Nat. Immunol. 3, 392.
Muller, M.R., et al. 2001. Immunology 103, 49.
Vergne, I., and Cezanne, L. 1999. Eur. J. Biochem. 264, 369.
Diaz-Guerra, M.J., et al. 1996. J. Biol. Chem. 271, 30114.
Offermanns, S., et al. 1992. Biochem. J. 282, 551.
Seifert, R., et al. 1990. Biochem. J. 267, 795.
Hoffmann, P., et al. 1989. Biol. Chem. Hoppe. Seyler. 370, 575.

Citations

Název
  • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision09-April-2018 JSW
    Synonyms(S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys₄-OH, 3HCl, P₃CSK₄, 3HCl, Pam₃Cys-SK₄, 3HCl, Pam3CSK4, TLR1/TLR2 Agonist I
    DescriptionA cell-permeable, water-soluble, synthetic, cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Induces the release of IL-1, IL-6, TNF-α, superoxide and NO. Promotes the translocation of NF-κB, enhances tyrosine protein phosphorylation, and activates ERK1/2 and MEK1/2. Acts as a selective TLR-2 (Toll-like receptor 2) agonist.
    FormLyophilized solid
    CAS number112208-00-1
    Chemical formulaC₈₁H₁₅₆N₁₀O₁₃S • 3 HCl
    Purity≥90% by HPLC
    SolubilityH₂O (2 mg/ml)
    Storage Protect from moisture
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
    Toxicity Standard Handling
    ReferencesBarrenschee, M., et al. 2010. PLoS One. 5, e13889.
    Zahringer, U., et al. 2008. Immunology. 213, 205.
    Toshchakov, V., et al. 2002. Nat. Immunol. 3, 392.
    Muller, M.R., et al. 2001. Immunology 103, 49.
    Vergne, I., and Cezanne, L. 1999. Eur. J. Biochem. 264, 369.
    Diaz-Guerra, M.J., et al. 1996. J. Biol. Chem. 271, 30114.
    Offermanns, S., et al. 1992. Biochem. J. 282, 551.
    Seifert, R., et al. 1990. Biochem. J. 267, 795.
    Hoffmann, P., et al. 1989. Biol. Chem. Hoppe. Seyler. 370, 575.
    Citation
  • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.
    		•