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540210 PTP Inhibitor III - CAS 29936-81-0 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α-Bromo-4-(carboxymethoxy)acetophenone, 4-(Carboxymethoxy)phenacyl Br, Protein Tyrosine Phosphatase Inhibitor III, SHP1 Inhibitor III, PTP-MEG2/PTPN9 Inhibitor, PTP-β Inhibitor, PTP-δ Inhibitor, PTP-ε Inhibitor, PTP-µ Inhibitor, PTP1B Inhibitor III, SHP2 Inhibitor II

Primary Target: protein tyrosine phosphatase (PTP)
540210
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
29936-81-0C₁₀H₉BrO₄
Description
Overview

This product has been discontinued.



A potent, cell-permeable, and covalent protein tyrosine phosphatase (PTP) inhibitor. Binds to SHP-1 (ΔSH2), the catalytic domain of the SH2 domain-containing phosphatase SHP-1, with lower affinity than PTP Inhibitor I (Cat. No. 540200) (Ki = 193 µM versus Ki = 43 µM) but with a higher kinact (1.8 min-1 versus 0.4 min-1). The inhibition can be reversed by irradiation of the inactivated PTP at 350 nm.
Catalogue Number540210
Brand Family Calbiochem®
Synonymsα-Bromo-4-(carboxymethoxy)acetophenone, 4-(Carboxymethoxy)phenacyl Br, Protein Tyrosine Phosphatase Inhibitor III, SHP1 Inhibitor III, PTP-MEG2/PTPN9 Inhibitor, PTP-β Inhibitor, PTP-δ Inhibitor, PTP-ε Inhibitor, PTP-µ Inhibitor, PTP1B Inhibitor III, SHP2 Inhibitor II
References
ReferencesArabaci, G., et al. 1999. J. Am. Chem. Soc. 121, 5085.
Product Information
CAS number29936-81-0
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₀H₉BrO₄
Chemical formulaC₁₀H₉BrO₄
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetprotein tyrosine phosphatase (PTP)
Primary Target IC<sub>50</sub>193 µM against PTP
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 34-36/37

Causes burns.
Irritating to eyes and respiratory system.
S PhraseS: 26-27-28-36/37/39

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Take off immediately all contaminated clothing.

Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Corrosive
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage ≤ -70°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsUnstable in DMSO; reconstitute just prior to use. Following initial thaw, aliquot and freeze (-70°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
540210 0

Documentation

PTP Inhibitor III - CAS 29936-81-0 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

PTP Inhibitor III - CAS 29936-81-0 - Calbiochem Certificates of Analysis

TitleLot Number
540210

References

Přehled odkazů
Arabaci, G., et al. 1999. J. Am. Chem. Soc. 121, 5085.

Brochure

Title
Protein Phosphatases Technical Bulletin
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-April-2011 RFH
Synonymsα-Bromo-4-(carboxymethoxy)acetophenone, 4-(Carboxymethoxy)phenacyl Br, Protein Tyrosine Phosphatase Inhibitor III, SHP1 Inhibitor III, PTP-MEG2/PTPN9 Inhibitor, PTP-β Inhibitor, PTP-δ Inhibitor, PTP-ε Inhibitor, PTP-µ Inhibitor, PTP1B Inhibitor III, SHP2 Inhibitor II
DescriptionA potent, cell-permeable, and covalent Protein Tyrosine Phosphatase (PTP) inhibitor. Binds to SHP-1(ΔSH2), the catalytic domain of the SH2 domain-containing phosphatase SHP-1, with lower affinity that PTP Inhibitor I (Cat. No. 540200) (Ki = 193 µM versus Ki = 43 mM) but with a higher kinact (1.8 min-1 versus 0.40 min-1). The inhibition can be reversed by irradiation of the inactivated PTP at 350 nm.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number29936-81-0
Chemical formulaC₁₀H₉BrO₄
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (200 mg/ml)
Storage Protect from light
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsUnstable in DMSO; reconstitute just prior to use. Following initial thaw, aliquot and freeze (-70°C).
Toxicity Corrosive
ReferencesArabaci, G., et al. 1999. J. Am. Chem. Soc. 121, 5085.