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540200 PTP Inhibitor I - CAS 2491-38-5 - Calbiochem

PTP Inhibitor I - CAS 2491-38-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Protein Tyrosine Phosphatase Inhibitor I, α-Bromo-4-hydroxyacetophenone, 4-Hydroxyphenacyl Br, SHP1 Inhibitor II

Primary Target: SHP-1
540200
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
2491-38-5C₈H₇BrO₂
Description
Overview

This product has been discontinued.



A potent, cell-permeable, and covalent protein tyrosine phosphatase (PTP) inhibitor. Inhibits SHP-1 (ΔSH2), the catalytic domain of the SH2 domain-containing phosphatase SHP-1 (Ki = 43 µM), and PTPIB (Ki = 42 µM). The inhibition can be reversed by irradiation of the inactivated PTP at 350 nm.
Catalogue Number540200
Brand Family Calbiochem®
SynonymsProtein Tyrosine Phosphatase Inhibitor I, α-Bromo-4-hydroxyacetophenone, 4-Hydroxyphenacyl Br, SHP1 Inhibitor II
References
ReferencesArabaci, G., et al. 1999. J. Am. Chem. Soc. 121, 5085.
Product Information
CAS number2491-38-5
ATP CompetitiveN
FormWhite powder
Hill FormulaC₈H₇BrO₂
Chemical formulaC₈H₇BrO₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetSHP-1
Primary Target IC<sub>50</sub>43 µM
Primary Target K<sub>i</sub>43 µM and 42 µM against SHP-1 and PTPIB, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 34-36/37

Causes burns.
Irritating to eyes and respiratory system.
S PhraseS: 26-27-28-36/37/39

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Take off immediately all contaminated clothing.

Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Corrosive
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage ≤ -70°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsUnstable in DMSO; reconstitute just prior to use.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
540200 0

Documentation

PTP Inhibitor I - CAS 2491-38-5 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

PTP Inhibitor I - CAS 2491-38-5 - Calbiochem Certificates of Analysis

TitleLot Number
540200

References

Přehled odkazů
Arabaci, G., et al. 1999. J. Am. Chem. Soc. 121, 5085.

Brochure

Title
Protein Phosphatases Technical Bulletin
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-May-2009 JSW
SynonymsProtein Tyrosine Phosphatase Inhibitor I, α-Bromo-4-hydroxyacetophenone, 4-Hydroxyphenacyl Br, SHP1 Inhibitor II
DescriptionA potent, cell-permeable, and covalent Protein Tyrosine Phosphatase (PTP) inhibitor. Inhibits SHP-1(ΔSH2), the catalytic domain of the SH2 domain-containing phosphatase SHP-1 (Ki = 43 µM) and PTP1B (Ki = 42 µM), The inhibition can be reversed by irradiation of the inactivated PTP at 350 nm. Unstable in solution.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number2491-38-5
Chemical formulaC₈H₇BrO₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (200 mg/ml)
Storage Protect from light
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsUnstable in DMSO; reconstitute just prior to use.
Toxicity Corrosive
ReferencesArabaci, G., et al. 1999. J. Am. Chem. Soc. 121, 5085.