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529505 PON1 Activator, ZNPA - CAS 42172-66-7 - Calbiochem

The PON1 Activator, ZNPA modulates the biological activity of PON1. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (Z)-2,3-bis (4-nitrophenyl)-acrylonitrile

529505
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
42172-66-7C₁₅H₉N₃O₄

Products

Katalogové čísloBalení ks/bal.
529505-10MG Skleněná láhev 10 mg
Description
OverviewA cell-permeable stilbene derivative that serves as an aryl hydrocarbon receptor (AhR) ligand and acts as a highly specific and potent inducer of paraoxonase 1 (PON1). Shown to be a better activator of PON1 mRNA (EC50 = 1 µM) and inducer of PON1 enzymatic activity (> 3 fold at 5 µM) when compared to resveratrol (Cat. No. 554325). However, it is devoid of any activity against estrogen receptors and is not shown to inhibit activity of tyrosine kinases. Also shown to antagonize the effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) on cytochrome P450 1A1 (CYP1A1).
Catalogue Number529505
Brand Family Calbiochem®
Synonyms(Z)-2,3-bis (4-nitrophenyl)-acrylonitrile
References
ReferencesGuyot, E., et al. 2011. Biochem. Pharm. 83, 627.
Product Information
CAS number42172-66-7
FormPale yellow solid
Hill FormulaC₁₅H₉N₃O₄
Chemical formulaC₁₅H₉N₃O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
529505-10MG 04055977269673

Documentation

PON1 Activator, ZNPA - CAS 42172-66-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

PON1 Activator, ZNPA - CAS 42172-66-7 - Calbiochem Certificates of Analysis

TitleLot Number
529505

References

Přehled odkazů
Guyot, E., et al. 2011. Biochem. Pharm. 83, 627.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-June-2012 JSW
Synonyms(Z)-2,3-bis (4-nitrophenyl)-acrylonitrile
DescriptionA cell-permeable stilbene derivative that serves as an aryl hydrocarbon receptor (AhR) ligand and acts as a highly specific and potent inducer of paraoxonase 1 (PON1). Shown to be a better activator of PON1 mRNA (EC50 = 1 µM) and inducer of PON1 enzymatic activity (> 3 fold at 5 µM) when compared to resveratrol (Cat. No. 554325). However, it is devoid of any activity against estrogen receptors and is not shown to inhibit activity of tyrosine kinases. Also shown to antagonize the effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) on cytochrome P450 1A1 (CYP1A1).
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number42172-66-7
Chemical formulaC₁₅H₉N₃O₄
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (25 mg/ml; pale yellow solution)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesGuyot, E., et al. 2011. Biochem. Pharm. 83, 627.