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505278 PNU 282987 - CAS 123464-89-1 - Calbiochem

PNU 282987 - CAS 123464-89-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PNU-282987, N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride, α7 nAChR Agonist, PNU 282987, alpha 7 Nicotinic Acetylcholine Receptor Agonist, PNU 282987, PNU282987

Primary Target: α7 nAChRs
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Tabulka spec. kláve

CAS #Empirical Formula
123464-89-1C₁₄H₁₇ClN₂O•HCl
Description
Overview

This product has been discontinued.



A potent agonist highly selective for α7 nAChRs (Ki = 26 nM). Used in investigating the roles of α7 nAChRs in sensory gating, learning and memory, cognitive functions, and treatment of Schizophrenia.
Catalogue Number505278
Brand Family Calbiochem®
SynonymsPNU-282987, N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride, α7 nAChR Agonist, PNU 282987, alpha 7 Nicotinic Acetylcholine Receptor Agonist, PNU 282987, PNU282987
References
ReferencesHajós, M., et al., 2010, Curr. Pharm. Des. 16, 538.
Bodnar, L., et al., 2005. J. Med. Chem. 48, 905.
Hajós, M., et al., 2005. J. Pharmacol. Exp. Ther. 312, 1213.
Product Information
CAS number123464-89-1
FormOff-white solid
Hill FormulaC₁₄H₁₇ClN₂O•HCl
Chemical formulaC₁₄H₁₇ClN₂O•HCl
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetα7 nAChRs
Primary Target K<sub>i</sub>26 nM
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
505278 0

Documentation

PNU 282987 - CAS 123464-89-1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Přehled odkazů
Hajós, M., et al., 2010, Curr. Pharm. Des. 16, 538.
Bodnar, L., et al., 2005. J. Med. Chem. 48, 905.
Hajós, M., et al., 2005. J. Pharmacol. Exp. Ther. 312, 1213.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-July-2013 JSW
SynonymsPNU-282987, N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride, α7 nAChR Agonist, PNU 282987, alpha 7 Nicotinic Acetylcholine Receptor Agonist, PNU 282987, PNU282987
DescriptionA potent agonist highly selective for α7 nAChRs (Ki = 26 nM). Used in investigating the roles of α7 nAChRs in sensory gating, learning and memory, cognitive functions, and treatment of Schizophrenia.
FormOff-white solid
CAS number123464-89-1
Chemical formulaC₁₄H₁₇ClN₂O•HCl
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityH₂O (100 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHajós, M., et al., 2010, Curr. Pharm. Des. 16, 538.
Bodnar, L., et al., 2005. J. Med. Chem. 48, 905.
Hajós, M., et al., 2005. J. Pharmacol. Exp. Ther. 312, 1213.