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526528 PIM-Kinase Inhibitor IX, SGI-1776 - CAS 1173928-26-1 - Calbiochem

The PIM-Kinase Inhibitor IX, SGI-1776 controls the biological activity of PIM-Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-((1-Methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, 2H₂SO₄

526528
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
1173928-26-1C₂₀H₂₂F₃N₅O • 2H₂SO₄
Description
OverviewA cell-permeable imidazopyridazine compound that acts as a potent, reversible and ATP-competitive inhibitor of Pim-1,2,3, Flt-3 and haspin kinase activities (IC50 = 7, 363, 69, 44 and 34 nM, respectively) with moderate (40% inhibition at 1 µM for c-kit) to excellent selectivity over CDKs, Aurora, Chk1, IKK, JNK, Abl, Raf, PKA, PKC and PI 3-K among 300-kinases. Shown to inhibit RNA synthesis, block phosphorylation of c-Myc-Ser62 and STAT3-Tyr705, and decrease c-Myc and Mcl-1 protein levels; cause cell cycle arrest and induce apoptosis in CLL lymphocytes and in AML cells, and efficiently arrest the growth of several prostate cancer cells (IC50 <10 µM).
Catalogue Number526528
Brand Family Calbiochem®
SynonymsN-((1-Methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, 2H₂SO₄
References
ReferencesChen, L.S., et al. 2011. Blood 118, 693.
Chang, M., et al. 2010. Mol. Cancer Ther. 9, 2478.
Mumenthaler, S.M., et al. 2009. Mol. Cancer Ther. 8, 2882.
Chen, L.S., et al. 2009. Blood 114, 4150.
Product Information
CAS number1173928-26-1
FormOff-white powder
Hill FormulaC₂₀H₂₂F₃N₅O • 2H₂SO₄
Chemical formulaC₂₀H₂₂F₃N₅O • 2H₂SO₄
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
526528 0

Documentation

PIM-Kinase Inhibitor IX, SGI-1776 - CAS 1173928-26-1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

PIM-Kinase Inhibitor IX, SGI-1776 - CAS 1173928-26-1 - Calbiochem Certificates of Analysis

TitleLot Number
526528

References

Přehled odkazů
Chen, L.S., et al. 2011. Blood 118, 693.
Chang, M., et al. 2010. Mol. Cancer Ther. 9, 2478.
Mumenthaler, S.M., et al. 2009. Mol. Cancer Ther. 8, 2882.
Chen, L.S., et al. 2009. Blood 114, 4150.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-July-2012 JSW
SynonymsN-((1-Methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, 2H₂SO₄
DescriptionA cell-permeable imidazopyridazine compound that acts as a potent, reversible and ATP-competitive inhibitor of Pim-1,2,3, Flt-3 and haspin kinase activities (IC50 = 7, 363, 69, 44 and 34 nM, respectively) with moderate (40% inhibition at 1 µM for c-kit) to excellent selectivity over CDKs, Aurora, Chk1, IKK, JNK, Abl, Raf, PKA, PKC and PI 3-K among 300-kinases. Shown to inhibit RNA synthesis, block phosphorylation of c-Myc-Ser62 and STAT3-Tyr705, and decrease c-Myc and Mcl-1 protein levels; cause cell cycle arrest and induce apoptosis in CLL lymphocytes and in AML cells, and efficiently arrest the growth of several prostate cancer cells (IC50 <10 µM).
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number1173928-26-1
Chemical formulaC₂₀H₂₂F₃N₅O • 2H₂SO₄
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (100 mg/ml; clear, nearly colorless solution) or H₂O (100 mg/ml; clear, nearly colorless solution)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesChen, L.S., et al. 2011. Blood 118, 693.
Chang, M., et al. 2010. Mol. Cancer Ther. 9, 2478.
Mumenthaler, S.M., et al. 2009. Mol. Cancer Ther. 8, 2882.
Chen, L.S., et al. 2009. Blood 114, 4150.