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538241 Nur77-p38 Interaction Inhibitor, PDNPA - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Pentyl 2-(3,5-dihydroxy-2-nonanoylphenyl)acetate, NR4A1 Inhibitor, PDNPA, TR3-p38 Interaction Inhibitor, PDNPA

Primary Target: Nur77
538241
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Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₂₂H₃₄O₅

Products

Katalogové čísloBalení ks/bal.
5.38241.0001 Skleněná láhev 10 mg
Description
OverviewA cell-permeable phenylacetate based compound that specifically blocks the Nur77-p38α interaction by directly targeting the ligand-binding domain of Nur77 (~1 to 10 µM) and impedes Nur77 phosphorylation by p38α. Does neither modulate p38α kinase activity nor affects the stability of the p38α-Nur77 complex. Inhibits p65 binding to DNA and blocks LPS-induced (100 ng/ml) NF-κB activity in RAW264.7 cells (IC50 = 1.6 µM), but does not affect the interaction between Nur77 and p65. Shown to reduce IL-6 concentration and prolong the lifespan of wild type mice treated with LPS. Also increases the survival rate of wild-type mice subjected to cecal ligation and puncture (CLP)-induced sepsis.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number538241
Brand Family Calbiochem®
SynonymsPentyl 2-(3,5-dihydroxy-2-nonanoylphenyl)acetate, NR4A1 Inhibitor, PDNPA, TR3-p38 Interaction Inhibitor, PDNPA
References
ReferencesLi, L., et al. 2015. Nat. Chem. Biol. 11, 339.
Product Information
FormWhite solid
Hill FormulaC₂₂H₃₄O₅
Chemical formulaC₂₂H₃₄O₅
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetNur77
Primary Target IC<sub>50</sub>1.6 µ
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
5.38241.0001 04054839116285

Documentation

Nur77-p38 Interaction Inhibitor, PDNPA - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Přehled odkazů
Li, L., et al. 2015. Nat. Chem. Biol. 11, 339.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-March-2017 JSW
SynonymsPentyl 2-(3,5-dihydroxy-2-nonanoylphenyl)acetate, NR4A1 Inhibitor, PDNPA, TR3-p38 Interaction Inhibitor, PDNPA
DescriptionA cell-permeable phenylacetate based compound that specifically blocks the Nur77-p38α interaction by directly targeting the ligand-binding domain of Nur77 (~1 to 10 µM) and impedes Nur77 phosphorylation by p38α. Does neither modulate p38α kinase activity nor affects the stability of the p38α-Nur77 complex. Inhibits p65 binding to DNA and blocks LPS-induced (100 ng/ml) NF-κB activity in RAW264.7 cells (IC50 = 1.6 µM), but does not affect the interaction between Nur77 and p65. Shown to reduce IL-6 concentration and prolong the lifespan of wild type mice treated with LPS. Also increases the survival rate of wild-type mice subjected to cecal ligation and puncture (CLP)-induced sepsis.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₂H₃₄O₅
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLi, L., et al. 2015. Nat. Chem. Biol. 11, 339.