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4801 Neomycin Sulfate - CAS 1405-10-3 - Calbiochem

Neomycin Sulfate, CAS 1405-10-3, is an aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
1405-10-3C₂₃H₄₆N₆O₁₃ . 3H₂SO₄
Description
OverviewAn aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes. Recently shown to inhibit angiogenin-induced angiogenesis. Blocks voltage-sensitive Ca2+ channels without affecting Na+ - Ca2+ antiporter in nerve cells. A potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release. An inhibitor of inositol phospholipid turnover. A non-specific phospholipase C inhibitor. Also inhibits phosphatidylcholine-phospholipase D activity (IC50 = 65 µM). Inhibits angiogenin-induced angiogenesis in the chicken chorioallantoic membrane (20 ng per egg).
Catalogue Number4801
Brand Family Calbiochem®
References
ReferencesHu, G.F. 1998. Proc. Natl. Acad. Sci. USA 95, 9791.
Wang, J.P., et al. 1996. J. Biol. Chem. 271, 8387.
Smith, M.J., et al. 1995. Dev. Biol. 167, 239.
Phillippe, M. 1994. Biochem. Biophys. Res. Commun. 205, 245.
Canzoniero, L.M., et al. 1993. Eur. J. Pharmacol. 245, 97.
Liscovitch, M., et al. 1991. Biochem. J. 279, 319.
Product Information
CAS number1405-10-3
Activity≥600 IU/mg
FormWhite solid
Hill FormulaC₂₃H₄₆N₆O₁₃ . 3H₂SO₄
Chemical formulaC₂₃H₄₆N₆O₁₃ . 3H₂SO₄
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
ApplicationNeomycin Sulfate, CAS 1405-10-3, is an aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes.
Biological Information
Primary Targetangiogenin-induced angiogenesis
Primary Target K<sub>i</sub>phosphatidylcholine-phospholipase D activity (IC₅₀ = 65 µM), inhibits angiogenin-induced angiogenesis in the chicken chorioallantoic membrane (20 ng per egg)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSQP4375000
Safety Information
R PhraseR: 42/43-60-61

May cause sensitization by inhalation and skin contact.
May impair fertility.
May cause harm to the unborn child.
S PhraseS: 22-36/37-45

Do not breathe dust.
Wear suitable protective clothing and gloves.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +15°C to +30°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store at room temperature (20°C). Stock solutions are stable for up to 3 months at 20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
4801 0

Documentation

Neomycin Sulfate - CAS 1405-10-3 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Neomycin Sulfate - CAS 1405-10-3 - Calbiochem Certificates of Analysis

TitleLot Number
4801

References

Přehled odkazů
Hu, G.F. 1998. Proc. Natl. Acad. Sci. USA 95, 9791.
Wang, J.P., et al. 1996. J. Biol. Chem. 271, 8387.
Smith, M.J., et al. 1995. Dev. Biol. 167, 239.
Phillippe, M. 1994. Biochem. Biophys. Res. Commun. 205, 245.
Canzoniero, L.M., et al. 1993. Eur. J. Pharmacol. 245, 97.
Liscovitch, M., et al. 1991. Biochem. J. 279, 319.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-October-2007 JSW
DescriptionAn aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes. Recetly shown to inhibit angiogenin-induced angiogenesis. Blocks voltage-sensitive Ca2+ channels without affecting the Na+-Ca2+ antiporter in nerve cells. A potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release. An inhibitor of inositol phospholipid turnover. A non-specific phosolipase C inhibitor. Also inhibits phophatidylcholine-phospholipase D activity (IC50 = 65 µM).
FormWhite solid
CAS number1405-10-3
RTECSQP4375000
Chemical formulaC₂₃H₄₆N₆O₁₃ . 3H₂SO₄
Structure formulaStructure formula
Activity≥600 IU/mg
SolubilityH₂O (6 mg/ml)
Storage Protect from moisture
Protect from light
+15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store at room temperature (20°C). Stock solutions are stable for up to 3 months at 20°C.
Toxicity Carcinogenic / Teratogenic
Merck USA index14, 6454
ReferencesHu, G.F. 1998. Proc. Natl. Acad. Sci. USA 95, 9791.
Wang, J.P., et al. 1996. J. Biol. Chem. 271, 8387.
Smith, M.J., et al. 1995. Dev. Biol. 167, 239.
Phillippe, M. 1994. Biochem. Biophys. Res. Commun. 205, 245.
Canzoniero, L.M., et al. 1993. Eur. J. Pharmacol. 245, 97.
Liscovitch, M., et al. 1991. Biochem. J. 279, 319.

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Kategorie

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Phospholipase Inhibitors
Life Science Research > Inhibitors and Biochemicals > Biochemicals > Antibiotics > Antimicrobial Agents