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454586 NMDAR2C/2D Inhibitor, DQP-1105 - CAS 380560-89-4 - Calbiochem

454586
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Tabulka spec. kláve

CAS #Empirical Formula
380560-89-4C₂₉H₂₄BrN₃O₄

Products

Katalogové čísloBalení ks/bal.
454586-10MG Skleněná láhev 10 mg
Description
OverviewA dihydroquinilone-pyrazoline NMDA antagonist, which is selective for NMDA receptors that are comprised of recombinant subunits GluN1/GluN2C (IC50 = 5.4 µM) and GluN1/GluN2D (2.2 µM) over GluN1/GluN2B (206 µM) and GluN1/ClucN2A (undetectable) in Xenopus oocytes. Similar selectivity is observed in whole-cell HEK patch-clamp assays with IC50 values for GluN2C and GluN2D that are at least 50-fold lower than those for recombinant GluN2A, GluN2B, GluA1, or GluK2-containing receptors. It inhibits NMDA by blocking a conformational change necessary for channel opening and is non-competitive with co-agonists, glutamate and glycine.
Catalogue Number454586
Brand Family Calbiochem®
SynonymsDQP-1105, NMDA Antagonist IV
References
ReferencesAcker, T., et al. 2011. Mol. Pharmacol. 80, 782.
Product Information
CAS number380560-89-4
FormYellow-white solid
Hill FormulaC₂₉H₂₄BrN₃O₄
Chemical formulaC₂₉H₂₄BrN₃O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥97% by HPLC
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
454586-10MG 04055977204193