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483120 NG-Nitro-L-arginine

NG-Nitro-L-arginine MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: L-NNA, NG-NO₂-L-Arg

Primary Target: bNOS
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
2149-70-4C₆H₁₃N₅O₄
Description
Overview

This product has been discontinued.





A cell-permeable, potent and reversible inhibitor of bNOS and eNOS (Ki = 25 nM for bNOS; Ki = 90 nM for eNOS). Inhibits iNOS at much higher concentrations (Ki = 8.1 µM). Causes a reduction in cardiac output and profound vasoconstriction.
Catalogue Number483120
Brand Family Calbiochem®
SynonymsL-NNA, NG-NO₂-L-Arg
References
ReferencesReif, D.W., and McCreedy, S.A. 1995. Arch. Biochem. Biophys. 320, 170.
Modin, A., et al. 1994. Neuroscience 62, 189.
Furfine, E.S., et al. 1993. Biochemistry 32, 8512.
Michel, A.D., et al. 1993. Br. J. Pharmacol. 109, 287.
Dawson, V.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 6368.
Moore, P.K., et al. 1990. Br. J. Pharmacol. 99, 408.
Product Information
CAS number2149-70-4
FormWhite to off-white lyophilized powder
Hill FormulaC₆H₁₃N₅O₄
Chemical formulaC₆H₁₃N₅O₄
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetbNOS
Primary Target K<sub>i</sub>25 nM
Secondary targeteNOS (Ki = 90 nM for eNOS), iNOS (Ki = 8.1 µM)
Purity≥99% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
483120 0

Documentation

NG-Nitro-L-arginine Certificates of Analysis

TitleLot Number
483120

References

Přehled odkazů
Reif, D.W., and McCreedy, S.A. 1995. Arch. Biochem. Biophys. 320, 170.
Modin, A., et al. 1994. Neuroscience 62, 189.
Furfine, E.S., et al. 1993. Biochemistry 32, 8512.
Michel, A.D., et al. 1993. Br. J. Pharmacol. 109, 287.
Dawson, V.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 6368.
Moore, P.K., et al. 1990. Br. J. Pharmacol. 99, 408.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-August-2008 RFH
SynonymsL-NNA, NG-NO₂-L-Arg
DescriptionA potent inhibitor of bNOS and eNOS (Ki = 25 nM for bNOS; Ki = 90 nM for eNOS). Also inhibits iNOS (Ki = 8.1 µM). Causes a reduction in cardiac output and profound vasoconstriction.
FormWhite to off-white lyophilized powder
CAS number2149-70-4
Chemical formulaC₆H₁₃N₅O₄
Structure formulaStructure formula
Purity≥99% by TLC
SolubilityH₂O
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesReif, D.W., and McCreedy, S.A. 1995. Arch. Biochem. Biophys. 320, 170.
Modin, A., et al. 1994. Neuroscience 62, 189.
Furfine, E.S., et al. 1993. Biochemistry 32, 8512.
Michel, A.D., et al. 1993. Br. J. Pharmacol. 109, 287.
Dawson, V.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 6368.
Moore, P.K., et al. 1990. Br. J. Pharmacol. 99, 408.

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Kategorie

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Nitric Oxide and Oxidative Stress > Nitric Oxide Synthase (NOS) Inhibitors