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203996 N-Butyldeoxynojirimycin, Hydrochloride - CAS 72599-27-0 - Calbiochem

A non-hormonal, alkylated iminosugar that acts as a transition state analog inhibitor of ceramide-specific glycosyltransferases and ER α-glucosidases I and II.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NB-DNJ, HCl, N-Butyl-DNJ, HCl

Primary Target: Ceramide-specific glycosyltransferases
203996
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
72599-27-0C₁₀H₂₁NO₄ · HCl
Description
OverviewA non-hormonal, alkylated iminosugar that acts as a transition state analog inhibitor of ceramide-specific glycosyltransferases and ER α-glucosidases I and II. Displays a broad-spectrum anti-viral activity by aiding the misfolding of glycoproteins. Shown to reversibly induce infertility in male mammals. Does not inhibit cell proliferation.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number203996
Brand Family Calbiochem®
SynonymsNB-DNJ, HCl, N-Butyl-DNJ, HCl
References
ReferencesDwek, R.A., et al. 2002. Nat. Rev. Drug Discovery 1, 65.
van der Spoel, A.C., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 17173.
Platt, F.M., et al. 1997. Science 276, 428.
Block, T.M., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 2235.
Platt, F.M., et al. 1994. J. Biol. Chem. 269, 8362.
Product Information
CAS number72599-27-0
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₀H₂₁NO₄ · HCl
Chemical formulaC₁₀H₂₁NO₄ · HCl
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCeramide-specific glycosyltransferases
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
203996 0

Documentation

N-Butyldeoxynojirimycin, Hydrochloride - CAS 72599-27-0 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

N-Butyldeoxynojirimycin, Hydrochloride - CAS 72599-27-0 - Calbiochem Certificates of Analysis

TitleLot Number
203996

References

Přehled odkazů
Dwek, R.A., et al. 2002. Nat. Rev. Drug Discovery 1, 65.
van der Spoel, A.C., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 17173.
Platt, F.M., et al. 1997. Science 276, 428.
Block, T.M., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 2235.
Platt, F.M., et al. 1994. J. Biol. Chem. 269, 8362.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision21-November-2014 JSW
SynonymsNB-DNJ, HCl, N-Butyl-DNJ, HCl
DescriptionA non-hormonal, alkylated imino sugar that acts as a transition state analog inhibitor of ceramide-specific glycosyltransferases and ER α-glucosidases I and II. Displays broad-spectrum anti-viral effects by inhibiting the processing of viral surface glycoproteins. Shown to reversibly induce infertility in male mammals.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number72599-27-0
Chemical formulaC₁₀H₂₁NO₄ · HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (1 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesDwek, R.A., et al. 2002. Nat. Rev. Drug Discovery 1, 65.
van der Spoel, A.C., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 17173.
Platt, F.M., et al. 1997. Science 276, 428.
Block, T.M., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 2235.
Platt, F.M., et al. 1994. J. Biol. Chem. 269, 8362.