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530655 Mitochondrial GPDH Inhibitor, iGP-1 - CAS 27031-00-1 - Calbiochem

A cell-permeable, potent, selective, and dose-dependent inhibitor of mitochondrial, but not cytosolic, sn-glycerol-3-phosphate dehydrogenase (IC₅₀ against mGPDH = 6.3 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(4-(1H-Benzoimidazol-2-yl)-phenyl)-succinamic acid, Mitochondrial sn-Glycerol-3-Phosphate Dehydrogenase Inhibitor, mGPDH Inhibitor, inhibitor of mGPDH 1, iGP1

Primary Target: mGPDH
530655
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Tabulka spec. kláve

CAS #Empirical Formula
27031-00-1C₁₇H₁₅N₃O₃

Products

Katalogové čísloBalení ks/bal.
5.30655.0001 Skleněná láhev 25 mg
Přidat k oblíbeným položkám
Description
OverviewA cell-permeable benzimidazolyl-phenylamidosuccinate compound that acts as a potent, selective, and dose-dependent inhibitor against mitochondrial, but not cytosolic, sn-glycerol-3-phosphate dehydrogenase (IC50 against mGPDH = 6.3 µM). Shown to directly interact with a single, allosteric binding site on mGPDH and displays mixed type of inhibition kinetics (Kic = 9.5 µM and Kiu = 14.6 µM, glycerol phosphate/GP-competitive against free and GP-uncompetitive against GP-bound mGPDH). Reduces H2O2 production by IQ site (IC50 = 13.6 µM) and inhibits ΔΨm driven by low concentrations of succinate (0.5 µM), but does not inhibit glutamate-, malate-, pyruvate-, or palmityoylcarnitine-driven ΔΨm. Does not prevent pyruvate uptake into cells or mitochondria and has no direct effect on Glycolysis in synaptosomes.
Catalogue Number530655
Brand Family Calbiochem®
SynonymsN-(4-(1H-Benzoimidazol-2-yl)-phenyl)-succinamic acid, Mitochondrial sn-Glycerol-3-Phosphate Dehydrogenase Inhibitor, mGPDH Inhibitor, inhibitor of mGPDH 1, iGP1
References
ReferencesOrr, A.L., et al. 2014. PLoS One 9, e89938.
Product Information
CAS number27031-00-1
FormBeige solid
Hill FormulaC₁₇H₁₅N₃O₃
Chemical formulaC₁₇H₁₅N₃O₃
Quality LevelMQ100
Biological Information
Primary TargetmGPDH
Primary Target IC<sub>50</sub>6.3 µ
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
5.30655.0001 04055977260427