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475851 Mitaplatin - Calbiochem

Mitaplatin - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: c,c,t-[Pt(NH₃)₂Cl₂(O₂CCHCl₂)₂]

475851
  
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Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₁₀H₂₂Cl₆N₄O₆Pt
Description
Overview

This product has been discontinued.



A cell-permeable Pt(IV) compound that, upon reduction inside cells, yields two molecules of the PDK (pyruvate dehydrogenase kinase) inhibitor DCA/dichloroacetate and one molecule of the apoptosis inducer Cisplatin (Cat. No. 232120). While the dual prodrug nature of Mitaplatin is shown to result in increased cell killing than Cisplatin in the human ovarian carcinoma A2780/CP70 cultures (IC50 = 3.34 and 6.0, respectively), the anticancer potency of Mitaplatin is often weaker than Cisplatin in other cancer cells tested, presumably due to insufficient prodrug reduction in these cells.

Note: Carboplatin, Cisplatin, and other platinum drugs are reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Solubilization with DMSO prior to culture treatment is not recommended.
Catalogue Number475851
Brand Family Calbiochem®
Synonymsc,c,t-[Pt(NH₃)₂Cl₂(O₂CCHCl₂)₂]
References
ReferencesHall, M.D., et al. 2014. Cancer Res. In press.
Dhar, S., and Lippard, S.J., 2009. Proc. Natl. Acad. Sci. USA 106, 22199.
Product Information
FormOff-white to cream solid
Hill FormulaC₁₀H₂₂Cl₆N₄O₆Pt
Chemical formulaC₁₀H₂₂Cl₆N₄O₆Pt
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by NMR
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 22-36-45

Do not breathe dust.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C. Use only fresh DMSO for reconstitution.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
475851 0

Documentation

Mitaplatin - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Mitaplatin - Calbiochem Certificates of Analysis

TitleLot Number
475851

References

Přehled odkazů
Hall, M.D., et al. 2014. Cancer Res. In press.
Dhar, S., and Lippard, S.J., 2009. Proc. Natl. Acad. Sci. USA 106, 22199.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-July-2014 JSW
Synonymsc,c,t-[Pt(NH₃)₂Cl₂(O₂CCHCl₂)₂]
DescriptionA cell-permeable Pt(IV) compound that, upon reduction inside cells, yields two molecules of the PDK (pyruvate dehydrogenase kinase) inhibitor DCA/dichloroacetate and one molecule of the apoptosis inducer Cisplatin (Cat. No. 232120). While the dual prodrug nature of Mitaplatin is shown to result in increased cell killing than Cisplatin in the human ovarian carcinoma A2780/CP70 cultures (IC50 = 3.34 and 6.0, respectively), the anticancer potency of Mitaplatin is often weaker than Cisplatin in other cancer cells tested, presumably due to insufficient prodrug reduction in these cells.

Note: Carboplatin, Cisplatin, and other platinum drugs are reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Solubilization with DMSO prior to culture treatment is not recommended.
FormOff-white to cream solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₀H₂₂Cl₆N₄O₆Pt
Structure formulaStructure formula
Purity≥95% by NMR
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C. Use only fresh DMSO for reconstitution.
Toxicity Harmful
ReferencesHall, M.D., et al. 2014. Cancer Res. In press.
Dhar, S., and Lippard, S.J., 2009. Proc. Natl. Acad. Sci. USA 106, 22199.