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FCMAB217F Milli-Mark™ Anti-CD235a-FITC Antibody, clone JC159

Detect CD235a using this Milli-Mark Anti-CD235a-FITC Antibody, clone JC159 validated for use in FC.

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Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology UniProt Number: P02724
FCMAB217F
100 tests  
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Tabulka spec. kláve

Species ReactivityKey ApplicationsHostFormatAntibody Type
HFCMFITCMonoclonal Antibody
Description
Catalogue NumberFCMAB217F
Trade Name
  • Milli-Mark
DescriptionMilli-Mark™ Anti-CD235a-FITC Antibody, clone JC159
Alternate Names
  • Glycophorin-A
  • PAS-2
  • Sialoglycoprotein alpha
  • MN sialoglycoprotein
Background InformationGlycophorin A, CD235a, is a single-pass membrane sialoglycoprotein and carrier of the blood group specificities M and N. The gene is located on chromosome 4q28-q31 and share sequence homology with genes encoding glycophorin B and glycophorin E (van der Schoot, 2002). Glycophorin A is expressed by erythroid cells beginning on morphologically recognizable erythroid precursors, just after the CFU-E stage, to the mature erythrocyte. Once glycophorin A is maximally expressed, the amount in each erythroid cell remains constant and does not appear to change during further maturation (Loken, 1987).
Product Information
FormatFITC
Control
  • Human Lymphocytes
PresentationPurified Mouse monoclonal IgG1 conjugated to FITC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.
Quality LevelMQ100
Applications
ApplicationDetect CD235a using this Milli-Mark Anti-CD235a-FITC Antibody, clone JC159 validated for use in FC.
Key Applications
  • Flow Cytometry
Biological Information
ImmunogenMembrane extracts of hairy cell leukemia prepared from human spleen
CloneJC159
HostMouse
SpecificityAntibody recognizes Human CD235a antigen.
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryGlycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB.
Purification MethodProtein A Purfied
UniProt Number
UniProt SummaryGlycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).
Molecular Weight 16 kDa (calculated)
Product Usage Statements
Quality AssuranceEvaluated by flow cytometry using human lymphocytes
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Packaging Information
Material Size100 tests
Global Trade Item Number
Katalogové číslo GTIN
FCMAB217F 04053252375514