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531068 Lenaldekar (LDK) - CAS 418800-15-4 - Calbiochem

An inhibitor of T cell proliferation (IC₅₀ = 3 µM in CD3+, CD4+, and CD8+ cells). Does not affect other cell types.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: T Cell Proliferation Inhibitor, LDK

531068
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
418800-15-4C₁₈H₁₄N₄

Products

Katalogové čísloBalení ks/bal.
5.31068.0001 Skleněná láhev 10 mg
Description
OverviewA quinolinyl hydrazone derived compound that specifically blocks the proliferation of T cells in a dose-dependent manner (IC50 = 3 µM in CD3+, CD4+, and CD8+ cells) without affecting other cell types. Its anti-proliferative effects are non-cytolytic in nature. Induces cell cycle delay at G2/M phase. Selectively induces apoptosis in human leukemic blasts and is shown to be active against all acute lymphoblastic leukemia cell lines (IC50 = 1 -2 µM) and also displays in vivo activity in a zebrafish T-ALL model. Reduces the growth of human T-ALL in murine xenograft models (16 mg/kg, i,p, b.i.d). Also shown to specifically block myelin specific T cell responses and reduce inflammation and demyelination in experimental autoimmune encephalomyelitis, possibly via its interactions with insulin-like growth factor-1 receptor. Diminishes the phosphorylation of T308 and S473 on Akt, however, its action is believed to be upstream of PI-3K/Akt. Does not affect the activity of over 450 other kinases in any significant manner. Exhibits a plasma t1/2 = 2 h.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number531068
Brand Family Calbiochem®
SynonymsT Cell Proliferation Inhibitor, LDK
References
ReferencesCusick, M.F., et al. 1999. PNAS. 96, 12192.
Ridges, S, et al. 2012. Blood. 119, 5621.
Product Information
CAS number418800-15-4
FormYellow powder
Hill FormulaC₁₈H₁₄N₄
Chemical formulaC₁₈H₁₄N₄
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary Target IC<sub>50</sub>3 µM to block proliferation of T lymphocytes
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
5.31068.0001 04055977242560

Documentation

Lenaldekar (LDK) - CAS 418800-15-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Přehled odkazů
Cusick, M.F., et al. 1999. PNAS. 96, 12192.
Ridges, S, et al. 2012. Blood. 119, 5621.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-August-2014 JSW
SynonymsT Cell Proliferation Inhibitor, LDK
DescriptionA quinolinyl hydrazone derived compound that specifically blocks the proliferation of T cells in a dose-dependent manner (IC50 = 3 µM in CD3+, CD4+, and CD8+ cells) without affecting other cell types. Its anti-proliferative effects are non-cytolytic in nature. Induces cell cycle delay at G2/M phase. Selectively induces apoptosis in human leukemic blasts and is shown to be active against all acute lymphoblastic leukemia cell lines (IC50 = 1 -2 µM) and also displays in vivo activity in a zebrafish T-ALL model. Reduces the growth of human T-ALL in murine xenograft models (16 mg/kg, i,p, b.i.d). Also shown to specifically block myelin specific T cell responses and reduce inflammation and demyelination in experimental autoimmune encephalomyelitis, possibly via its interactions with insulin-like growth factor-1 receptor. Diminishes the phosphorylation of T308 and S473 on Akt, however, its action is believed to be upstream of PI-3K/Akt. Does not affect the activity of over 450 other kinases in any significant manner. Exhibits a plasma t1/2 = 2 h.
FormYellow powder
Intert gas (Yes/No) Packaged under inert gas
CAS number418800-15-4
Chemical formulaC₁₈H₁₄N₄
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesCusick, M.F., et al. 1999. PNAS. 96, 12192.
Ridges, S, et al. 2012. Blood. 119, 5621.