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420148 JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem

The JAK3/GSK-3β/PKCα Inhibitor, also referenced under CAS 1260181-14-3, controls the biological activity of JAK3/GSK-3β/PKCα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(5-(4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1-yl)-2-trifluoromethyl-phenyl)-4-(1H-indol-3-yl)-pyrrole-2,5-dione, NIBR3049, JAK3 Inhibitor XII

420148
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
1260181-14-3C₂₇H₂₅F₃N₄O₄

Products

Katalogové čísloBalení ks/bal.
420148-5MG Skleněná láhev 5 mg
Description
OverviewA cell-permeable phenyl-indolyl maleimide compound that acts as a potent, ATP-binding site targeting and reversible inhibitor of GSK-3β, JAK3, PKCα and PKCθ (IC50 = 3, 8, 13 and 68 nM, respectively) with excellent selectivity over 40-kinases, including JAK1, JAK2 and Tyk2 (IC50 = 1.017, 2.55 and 8.055 µM, respectively). Shown to efficiently block interleukin stimulated STAT5 phosphorylation and T cell costimulation (IC50 = 0.525, 1.294 and 0.689 µM in IL15-MO7, IL2-CTLL and TCR/CD28-Jurkat cells, respectively).
Catalogue Number420148
Brand Family Calbiochem®
Synonyms3-(5-(4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1-yl)-2-trifluoromethyl-phenyl)-4-(1H-indol-3-yl)-pyrrole-2,5-dione, NIBR3049, JAK3 Inhibitor XII
References
ReferencesHaan, C., et al. 2011. Chem. Biol. 18, 314.
Thoma, G., et al. 2011. J. Med. Chem. 54, 284.
Product Information
CAS number1260181-14-3
FormYellow solid
Hill FormulaC₂₇H₂₅F₃N₄O₄
Chemical formulaC₂₇H₂₅F₃N₄O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
420148-5MG 04055977210699

Documentation

JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem Certificates of Analysis

TitleLot Number
420148

References

Přehled odkazů
Haan, C., et al. 2011. Chem. Biol. 18, 314.
Thoma, G., et al. 2011. J. Med. Chem. 54, 284.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-July-2012 JSW
Synonyms3-(5-(4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1-yl)-2-trifluoromethyl-phenyl)-4-(1H-indol-3-yl)-pyrrole-2,5-dione, NIBR3049, JAK3 Inhibitor XII
DescriptionA cell-permeable phenyl-indolyl maleimide compound that acts as a potent, ATP-binding site targeting and reversible inhibitor of GSK-3β, JAK3, PKCα and PKCθ (IC50 = 3, 8, 13 and 68 nM, respectively) with excellent selectivity over 40-kinases, including JAK1, JAK2 and Tyk2 (IC50 = 1.017, 2.55 and 8.055 µM, respectively). Shown to efficiently block interleukin stimulated STAT5 phosphorylation and T cell costimulation (IC50 = 0.525, 1.294 and 0.689 µM in IL15-MO7, IL2-CTLL and TCR/CD28-Jurkat cells, respectively).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1260181-14-3
Chemical formulaC₂₇H₂₅F₃N₄O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHaan, C., et al. 2011. Chem. Biol. 18, 314.
Thoma, G., et al. 2011. J. Med. Chem. 54, 284.