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402086 Indirubin-3ʹ-monoxime, 5-Iodo- - CAS 331467-03-9 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Gsk-3β
402086
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
331467-03-9C₁₆H₁₀IN₃O₂
Description
Overview

This product has been discontinued.



A highly potent cell-permeable and reversible inhibitor of glycogen synthase kinase-3β (GSK-3β; IC50 = 9 nM). Also inhibits Cdk1 (IC50 = 25 nM) and Cdk5 (IC50 = 20 nM) activities. Acts by binding to the ATP-binding pocket of these enzymes.
Catalogue Number402086
Brand Family Calbiochem®
References
ReferencesLeclerc, S., et al. 2001. J. Biol. Chem. 276, 251.
Hoessel, R., et al. 1999. Nat. Cell Biol. 1, 60.
Product Information
CAS number331467-03-9
ATP CompetitiveY
FormDark red solid
Hill FormulaC₁₆H₁₀IN₃O₂
Chemical formulaC₁₆H₁₀IN₃O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGsk-3β
Primary Target IC<sub>50</sub>9 nM against GSK-3β
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
402086 0

Documentation

Indirubin-3ʹ-monoxime, 5-Iodo- - CAS 331467-03-9 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Indirubin-3ʹ-monoxime, 5-Iodo- - CAS 331467-03-9 - Calbiochem Certificates of Analysis

TitleLot Number
402086

References

Přehled odkazů
Leclerc, S., et al. 2001. J. Biol. Chem. 276, 251.
Hoessel, R., et al. 1999. Nat. Cell Biol. 1, 60.

Brochure

Title
Alzheimer's Disease Brochure & Technical Guide
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
DescriptionA highly potent, cell-permeable, and reversible inhibitor of glycogen synthase kinase-3β (GSK-3β) (IC50 = 9 nM). Reported to inhibit GSK-3β phosphorylation of human tau protein in vitro (IC50 ~100 nM) and in cells (effective concentration = 20 µM). Also inhibits CDK1 (IC50 = 25 nM) and CDK5 (IC50 = 20 nM). Shown to inhibit phosphorylation of DARPP-32 by CDK5 in brain sections enriched for DARPP-32. Inhibition is competitive with respect to ATP.
FormDark red solid
Intert gas (Yes/No) Packaged under inert gas
CAS number331467-03-9
Chemical formulaC₁₆H₁₀IN₃O₂
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesLeclerc, S., et al. 2001. J. Biol. Chem. 276, 251.
Hoessel, R., et al. 1999. Nat. Cell Biol. 1, 60.