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373270 Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1 - CAS 313553-47-8 - Calbiochem

373270
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Tabulka spec. kláve

CAS #Empirical Formula
313553-47-8C₁₈H₁₆N₂OS

Products

Katalogové čísloBalení ks/bal.
373270-10MG 10 mg
Description
OverviewA cell-permeable thiazolyl benzamide compound that directly binds Hec1 and disrupts Hec1/Nek2 complex formation, resulting in defective Hec1 kinetochores localization and cellular Nek2 destabilization/downregulation. Shown to induce a transient mitotic arrest in HeLa cultures and inhibit the proliferation of 10 breast cancer cell lines (GI50 of 10-21 µM) as well as the cervical HeLa and colon HCT116 cancer lines, while exhibiting reduced potency against the noncancerous MCF10A line (GI50 = 41 µM). Reported to suppress the MDA-MB-468-derived tumor growth (by ~53% and ~75% 3 wks after a 7-wk treatment period with 50 mg/kg and 100 mg/kg INH1, repectively, i.p.) in a murine breast cancer model in vivo.
Catalogue Number373270
Brand Family Calbiochem®
SynonymsN-(4-(2,4-Dimethylphenyl)-thiazol-2-yl)-benzamide, INH1, Inhibitor of Nek2/Hec1-1
References
ReferencesWu, G., et al. 2008. Cancer Res. 68, 8393.
Product Information
CAS number313553-47-8
FormWhite solid
Hill FormulaC₁₈H₁₆N₂OS
Chemical formulaC₁₈H₁₆N₂OS
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥97% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
373270-10MG 04055977191011