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508194 HDAC6 Inhibitor III - Calbiochem

A cell-permeable, potent and selective inhibitor of histone deacetylase 6 (HDAC6; IC₅₀ = 29 nM).

HDAC6 Inhibitor III - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: HDAC6
508194
  
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Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₂₀H₁₉N₃O₃
Description
Overview

This product has been discontinued.



A cell-permeable, quinazolin-4-one based hydroxamic acid containing compound that acts as a potent and selective inhibitor of histone deacetylase 6 (HDAC6; IC50 = 29 nM). Exhibits high selectivity over other HDACs (IC50 = 1.88, 6.45, 1.75, and 4.08 µM for HDAC1, 2, 8, and 11, respectively). Does not affect hERG activity (>10 µM) or p450 activity (IC50 > 6.5 µM). Blocks b-amyloid (Ab) aggregation in the presence of zinc (IC50 = 9.5 µM) and improves learning-based performance in mice. Induces neurite outgrowth (EC50 = 7.3 and 9.2 µM in PC12 and SH-SY5Y cells, respectively) and enhances synaptic activity (EC50 = 6.5 and 6.8 µM in PC12 and SH-SY5Y cells, respectively). Shown to enhance acetylated a-tubulin levels in hippocampus region of mice with Ab lesions.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Catalogue Number508194
Brand Family Calbiochem®
References
ReferencesYu, C.W., et al. 2013. J. Med. Chem. 56, 6775.
Product Information
FormCream powder
Hill FormulaC₂₀H₁₉N₃O₃
Chemical formulaC₂₀H₁₉N₃O₃
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetHDAC6
Primary Target IC<sub>50</sub>29 nM
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
508194 0

Documentation

HDAC6 Inhibitor III - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Přehled odkazů
Yu, C.W., et al. 2013. J. Med. Chem. 56, 6775.

Technical Info

Title
White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-June-2014 JSW
DescriptionA cell-permeable, quinazolin-4-one based hydroxamic acid containing compound that acts as a potent and selective inhibitor of histone deacetylase 6 (HDAC6; IC50 = 29 nM). Exhibits high selectivity over other HDACs (IC50 = 1.88, 6.45, 1.75, and 4.08 µM for HDAC1, 2, 8, and 11, respectively). Does not affect hERG activity (>10 µM) or p450 activity (IC50 > 6.5 µM). Blocks b-amyloid (Ab) aggregation in the presence of zinc (IC50 = 9.5 µM) and improves learning-based performance in mice. Induces neurite outgrowth (EC50 = 7.3 and 9.2 µM in PC12 and SH-SY5Y cells, respectively) and enhances synaptic activity (EC50 = 6.5 and 6.8 µM in PC12 and SH-SY5Y cells, respectively). Shown to enhance acetylated a-tubulin levels in hippocampus region of mice with Ab lesions.
FormCream powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₀H₁₉N₃O₃
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesYu, C.W., et al. 2013. J. Med. Chem. 56, 6775.